Additive effects of medroxyprogesterone acetate and 5-fluorouracil derivative on 7,12-dimethylbenz-[a]anthracene-induced rat mammary tumors
| Autor: | Isao Okayasu, Yukichi Hara, Kuwa K, Satoe Suzuki, Shinobu Sakamoto, Hideki Kudo, Hisashi Shinoda, Shuji Sassa, Mitamura T |
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| Rok vydání: | 1998 |
| Předmět: |
Cancer Research
Transcription Genetic 9 10-Dimethyl-1 2-benzanthracene Medroxyprogesterone Acetate Pharmacology Polymerase Chain Reaction Thymidine Kinase Thymidylate synthase Rats Sprague-Dawley chemistry.chemical_compound Bone Density Oral administration Antineoplastic Combined Chemotherapy Protocols medicine Animals Medroxyprogesterone acetate Pharmacology (medical) RNA Messenger Progesterone Tegafur Mammary tumor Estradiol biology 7 12-Dimethylbenz[a]anthracene Mammary Neoplasms Experimental Uracil Organ Size Thymidylate Synthase Rats Oncology chemistry Thymidine kinase Fluorouracil biology.protein Female medicine.drug |
| Zdroj: | Anti-Cancer Drugs. 9:351-358 |
| ISSN: | 0959-4973 |
| DOI: | 10.1097/00001813-199804000-00009 |
| Popis: | Chronic oral administration of 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil suppressed thymidylate synthetase (TS) gene expression followed by reduction of TS activity in rat mammary tumors induced with 7,12-dimethylbenz[a]anthracene. Addition of medroxyprogesterone acetate (MPA) to the anticancer drug caused an additional decrease in TS and thymidine kinase activities in the tumor growth and restoration of bone loss. These results suggest that the simultaneous administration of MPA and anticancer drugs causes increased inhibition of mammary tumor growth and also diminishes the bone loss. |
| Databáze: | OpenAIRE |
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