VEGF-R1 as a Potential Molecular Target for Anticancer Therapy
| Autor: | S. I. Nikulitskiy, E. G. Tyrsina, O. O. Ryabaya, A. N. Inshakov |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Biophysics Active Transport Cell Nucleus Tumor cells Antineoplastic Agents Malignancy Biochemistry Targeted therapy Protein content 03 medical and health sciences 0302 clinical medicine Cell Line Tumor medicine Humans 030212 general & internal medicine Molecular Targeted Therapy Receptor Cell Nucleus Chemistry General Chemistry General Medicine medicine.disease Gene Expression Regulation Neoplastic 030104 developmental biology medicine.anatomical_structure Receptors Vascular Endothelial Growth Factor Cancer research Molecular targets Nucleus |
| Zdroj: | Doklady. Biochemistry and biophysics. 478(1) |
| ISSN: | 1608-3091 |
| Popis: | The possibility of using VEGF-R1 receptor for targeted therapy in oncology was investigated. Using the approach to measuring the protein content in intact nuclei of cells, which was developed by us, we showed the presence of this receptor in the nuclei of tumor, but not normal cells. A direct correlation between the level of VEGF-R1 expression in the nucleus and the degree of malignancy of tumor cells, indicating the prognostic value of this parameter, was found. The mechanisms of the functioning of this receptor and the pathways of inhibiting its activity are discussed, and the validity of the selection of VEGF-R1 as a molecular target for anticancer therapy is conformed. |
| Databáze: | OpenAIRE |
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