Cyclin A in nonfunctioning pituitary adenomas
| Autor: | Elisa Baranski Lamback, Alexandro Guterres, Leandro Kasuki, Monique Alvares Barbosa, Debora Aparecida Silva, Carlos Henrique de Azeredo Lima, Leila Chimelli, Mônica R. Gadelha, Aline Helen da Silva Camacho |
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| Rok vydání: | 2020 |
| Předmět: |
Adenoma
Pituitary gland Endocrinology Diabetes and Metabolism Cyclin A 030209 endocrinology & metabolism medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Endocrinology Diabetes mellitus Biomarkers Tumor medicine Humans Pituitary Neoplasms Tumor size biology business.industry medicine.disease Fold change Ki-67 Antigen medicine.anatomical_structure 030220 oncology & carcinogenesis Cancer research biology.protein Neoplasm Recurrence Local Quantitative Real-Time Polymerase Chain Reaction Carcinogenesis business |
| Zdroj: | Endocrine. 70:380-387 |
| ISSN: | 1559-0100 1355-008X |
| DOI: | 10.1007/s12020-020-02402-5 |
| Popis: | Assess cyclin A in nonfunctioning pituitary adenomas (NFPA) and compare its expression in non-invasive and non-proliferative tumors with invasive and proliferative tumors (12× higher risk of recurrence). Quantitative real time polymerase chain reaction to analyze cyclin A using normal pituitary gland as reference. Fold change (FC) > 1 was considered as increased. Tumor invasion was based on Knosp criteria (grades 3–4 considered invasive) and proliferation on the presence of at least two of three criteria: Ki-67 ≥ 3%; mitoses > 2/10; positive p53. Both groups were compared with Mann–Whitney test considering p value |
| Databáze: | OpenAIRE |
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