Association between MTHFR variant and diabetic neuropathy
| Autor: | Armita Kakavand Hamidi, Mania Radfar, Mahsa M. Amoli |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Diabetic neuropathy Type 2 diabetes Iran 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences 0302 clinical medicine Diabetic Neuropathies Gene Frequency Risk Factors Diabetes mellitus Internal medicine medicine Humans Genetic Predisposition to Disease 030212 general & internal medicine Genotyping Genetic Association Studies Methylenetetrahydrofolate Reductase (NADPH2) Pharmacology Polymorphism Genetic biology business.industry General Medicine Middle Aged medicine.disease digestive system diseases Pathophysiology Surgery Phenotype Peripheral neuropathy Diabetes Mellitus Type 2 Case-Control Studies Methylenetetrahydrofolate reductase biology.protein Female Restriction fragment length polymorphism business |
| Zdroj: | Pharmacological Reports. 70:1-5 |
| ISSN: | 1734-1140 |
| Popis: | Background Methylene-tetrahydrofolate reductase (MTHFR) gene variant may play an important role in the pathophysiology of diabetes and its complications due to its influence on plasma homocysteine levels and also its effect on scavenging peroxynitrite radicals. Diabetic peripheral neuropathy (DPN) is one of the most common diabetic chronic complications. The aim of this study was to investigate the relationship between diabetic neuropathy and MTHFR gene C677T and 1298A ⁄C polymorphisms. Method Patients with type 2 diabetes N = 248 were enrolled in the study, consisting of patients with neuropathy (N = 141) and patients without neuropathy (N = 107). MTHFR C677T polymorphism was analyzed using polymerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP) of genomic DNA for genotyping of samples. 1298A/C polymorphism was evaluated using ARMS-PCR. Result There was a significant difference in MTHFR polymorphism between the groups with and without neuropathy. Conclusion Our results suggest that MTHFR 677 variant confer risk for diabetic neuropathy among Iranian patients with type 2 diabetes. |
| Databáze: | OpenAIRE |
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