Long-term functional outcome of distal radius fractures is associated with early post-fracture bone stiffness of the fracture region: An HR-pQCT exploratory study
| Autor: | J. van den Bergh, Piet Geusens, S. M. J. van Kuijk, Frans Heyer, J.J.A. de Jong, B. van Rietbergen, Martijn Poeze, Paul C. Willems, Jacobus J. Arts, S.G.P. Bours |
|---|---|
| Přispěvatelé: | Interne Geneeskunde, Promovendi NTM, RS: NUTRIM - R3 - Respiratory & Age-related Health, Beeldvorming, RS: MHeNs - R3 - Neuroscience, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Orthopedie, MUMC+: MA Orthopedie (9), RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation, MUMC+: MA Reumatologie (9), RS: CAPHRI - R5 - Optimising Patient Care, MUMC+: KIO Kemta (9), Epidemiologie, RS: CAPHRI - R2 - Creating Value-Based Health Care, MUMC+: MA Heelkunde (9), MUMC+: NAZL en ROAZ (9), Surgery, Orthopaedic Biomechanics |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Histology Time Factors Bone density Physiology Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Fracture healing Bone healing Wrist Wrist pain SDG 3 – Goede gezondheid en welzijn 03 medical and health sciences Disability Evaluation 0302 clinical medicine SDG 3 - Good Health and Well-being medicine Humans COMPUTED-TOMOGRAPHY Aged Orthodontics HR-pQCT business.industry DISABILITY Finite element analysis Stiffness PAIN Radius Bone fracture Middle Aged Functional outcome medicine.disease Biomechanical Phenomena 030104 developmental biology medicine.anatomical_structure DENSITY Fracture (geology) Female medicine.symptom business Radius Fractures Tomography X-Ray Computed |
| Zdroj: | Bone, 127, 510-516. Elsevier Science Bone, 127, 510-516. Elsevier |
| ISSN: | 8756-3282 |
| Popis: | Identifying determinants of long-term functional outcome after a distal radius fracture is challenging. Previously, we reported on the association between early HR-pQCT measurements and clinical outcome 12 weeks after a conservatively treated distal radius fracture. We extended the follow-up and assessed functional outcome after two years in relation to early HR-pQCT derived bone parameters.HR-pQCT scans of the fracture region were performed in 15 postmenopausal women with a distal radius fracture at 1-2 (baseline), 3-4 weeks and 26 months post-fracture. Additionally, the contralateral distal radius was scanned at baseline. Bone density, micro-architecture parameters and bone stiffness using micro-finite element analysis (FEA) were evaluated. During all visits, wrist pain and function were assessed using the patient-rated wrist evaluation questionnaire (PRWE), quantifying functional outcome with a score between 0 and 100.Two-year PRWE was associated with torsional and bending stiffness 3-4 weeks post-fracture (R-2: 0.49, p = 0.006 and R-2: 0.54, p = 0.003, respectively). In contrast, early micro-architecture parameters of the fracture region or contralateral bone parameters did not show any association with long-term outcome.This exploratory study indicates that HR-pQCT with mu FEA performed within four weeks after a distal radius fracture captures biomechanical fracture characteristics that are associated with long-term functional outcome and therefore could be a valuable early outcome measure in clinical trials and clinical practice. |
| Databáze: | OpenAIRE |
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