Cross-reactivity between Chlamydia trachomatis heat shock protein 10 and early pregnancy factor
| Autor: | J. A. Machado-Caetano, Nicolas Guillaume, Jacques Mention, Sandra Romão, Jeanne Orfila, Maria Anjos Catry, Maria José Borrego, Jean Marie Sueur, Fotini Betsou, Nicole Faille |
|---|---|
| Přispěvatelé: | NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) |
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Male
AUTOIMMUNITY Clinical Biochemistry Chlamydia trachomatis Pregnancy Proteins medicine.disease_cause Pregnancy Chaperonin 10 Immunology and Allergy HLA-DR Serological Subtypes biology Female infertility Antibodies Bacterial Female Antibody Infertility Female Adult Infertility Microbiology (medical) Adolescent medicine.drug_class Immunology Cross Reactions Monoclonal antibody CLONING HLA-DQ Antigens Heat shock protein Suppressor Factors Immunologic medicine Humans Autoantibodies Antigens Bacterial PURIFICATION HLA-DQ Antigen IDENTIFICATION HLA-DR Antigens Chlamydia Infections ALLELES medicine.disease MICE Haplotypes Antibody Formation biology.protein Microbial Immunology MONOCLONAL-ANTIBODIES Peptides HUMAN CHAPERONIN-10 |
| Popis: | Chlamydia trachomatis heat shock protein 10 (Chsp10) is associated with chronic genital tract infection with C. trachomatis . Chsp10 is homologous to human chaperonin 10 (Cpn10) and early pregnancy factor (EPF), a form of human Cpn10 that is specifically secreted at the start of pregnancy. We investigated cross-reactions between serum anti-Chsp10 antibodies and anti-EPF antibodies in pregnant and nonpregnant patients. Pregnancy was found to be associated with the presence of anti-EPF antibodies, which are specifically induced in pregnant women with a history of C. trachomatis infection, and with the presence of serum anti-Chsp10 antibodies. We also found that infertility was associated with the presence of anti-Chsp10 and anti-EPF antibodies. The HLA class II haplotype DR8 DQ4 was associated with the presence of anti-Chsp10 antibodies but not of anti-EPF antibodies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|