Modification of some markers of inflammation during treatment for acute respiratory exacerbation in cystic fibrosis
| Autor: | G. Mastella, Enrico Valletta, A Rigo, L. Bonazzi, L. Zanolla |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Pancreatic disease Adolescent Cystic Fibrosis Exacerbation Immunoglobulins Cystic fibrosis Blood serum Anti-Infective Agents medicine Humans Pseudomonas Infections Child Glycoproteins Haptoglobins Pancreatic Elastase medicine.diagnostic_test biology business.industry Respiratory disease Haptoglobin Ceruloplasmin Blood Proteins Pneumonia General Medicine medicine.disease Fibronectins Child Preschool Erythrocyte sedimentation rate Acute Disease Pediatrics Perinatology and Child Health Immunology Absolute neutrophil count biology.protein Female Drug Monitoring business Biomarkers Granulocytes |
| Zdroj: | Acta Paediatrica. 81:227-230 |
| ISSN: | 1651-2227 0803-5253 |
| DOI: | 10.1111/j.1651-2227.1992.tb12209.x |
| Popis: | An objective approach for monitoring the treatment of acute pulmonary exacerbation in cystic fibrosis was evaluated. Eleven biochemical markers of inflammation (erythrocyte sedimentation rate, neutrophil count, C-reactive protein, alpha-1 antitrypsin, haptoglobin, ceruloplasmin, fibronectin, alpha-1 glycoprotein, alpha-2 macroglobulin, C3, granulocyte elastase and anti-Pseudomonas IgG) were measured in blood serum and plasma from 46 cystic fibrosis patients with chronic Pseudomonas aeruginosa colonization before and after treatment. The overall outcome in each patient was evaluated by means of a pondered sum of clinical, chest X-ray and lung function scores. Biochemical markers were related to the overall clinical improvement: haptoglobin, ceruloplasmin, fibronectin and alpha-1 glycoprotein showed a good sensitivity (64-70%), specificity (60-70%) and positive predictive value (86-89%). Granulocyte elastase showed a similar sensitivity (67%) and positive predictive value (85%) but a lower specificity (33%). The negative predictive value was generally poor (32-39%). Our data suggest that the combined measurement of some markers of inflammation and of conventional clinical parameters, may help in evaluating the efficacy of anti-infective treatment in cystic fibrosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text