Application of a Reactive Oxygen Species-Responsive Drug-Eluting Coating for Surface Modification of Vascular Stents
| Autor: | Changqi Liu, Jin Wang, Kebing Wang, Tengda Shang, Lu Zhang, Yudie Fu, Lei Zhou, Xin Li, Yuancong Zhao |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Materials science Biocompatibility Myocytes Smooth Muscle Cystamine Neovascularization Physiologic engineering.material Pharmacology medicine.disease_cause Catechin Coronary Restenosis Rats Sprague-Dawley Coating Restenosis Coated Materials Biocompatible In vivo Cell Movement medicine Animals General Materials Science Cells Cultured Cell Proliferation chemistry.chemical_classification Reactive oxygen species Macrophages Endothelial Cells Drug-Eluting Stents medicine.disease Stainless Steel Drug Liberation chemistry engineering Quinolines Surface modification Rabbits Drug carrier Reactive Oxygen Species Oxidation-Reduction Oxidative stress |
| Zdroj: | ACS applied materialsinterfaces. 13(30) |
| ISSN: | 1944-8252 |
| Popis: | Stent implantation is the primary method used to treat coronary heart disease. However, it is associated with complications such as restenosis and late thrombosis. Despite surface modification being an effective way to improve the biocompatibility of stents, the current research studies are not focused on changes in the vascular microenvironment at the implantation site. In the present study, an adaptive drug-loaded coating was constructed on the surface of vascular stent materials that can respond to oxidative stress at the site of vascular lesions. Two functional molecules, epigallocatechin gallate (EGCG) and cysteine hydrochloride, were employed to fabricate a coating on the surface of 316L stainless steel. In addition, the coating was used as a drug carrier to load pitavastatin calcium. EGCG has antioxidant activity, and pitavastatin calcium can inhibit smooth muscle cell proliferation. Therefore, EGCG and pitavastatin calcium provided a synergistic anti-inflammatory effect. Moreover, the coating was cross-linked using disulfide bonds, which accelerated the release of the drug in response to reactive oxygen species. A positive correlation was observed between the rate of drug release and the degree of oxidative stress. Collectively, this drug-loaded oxidative stress-responsive coating has been demonstrated to significantly inhibit inflammation, accelerate endothelialization, and reduce the risk of restenosis of vascular stents in vivo. |
| Databáze: | OpenAIRE |
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