Evaluation of the Risk Factors for Acute Kidney Injury in Neonates Exposed to Antenatal Indomethacin
| Autor: | Donna M. Kraus, Kirsten H. Ohler, Jessica L. Jacobson, Gregory S. Calip, Jennifer T. Pham |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.industry Incidence (epidemiology) Clinical Investigations Acute kidney injury Renal function urologic and male genital diseases medicine.disease Affect (psychology) Internal medicine Pediatrics Perinatology and Child Health medicine Pharmacology (medical) business |
| Zdroj: | J Pediatr Pharmacol Ther |
| ISSN: | 1551-6776 |
| Popis: | OBJECTIVEEvidence is limited about important maternal and neonatal risk factors that affect neonatal renal function. The incidence of acute kidney injury (AKI) and identification of associated risk factors in neonates exposed to antenatal indomethacin was studied.METHODSA retrospective cohort of neonates exposed to antenatal indomethacin within 1 week of delivery was analyzed for development of AKI up to 15 days of life. Adjusted hazard ratios (HRs) and 95% CIs for AKI risk were calculated in time-dependent Cox proportional hazards models.RESULTSAmong 143 neonates with mean gestational age of 28.3 ± 2.4 weeks, AKI occurred in 62 (43.3%), lasting a median duration of 144 hours (IQR, 72–216 hours). Neonates with AKI had greater exposure to postnatal NSAIDs (48.4% vs 9.9%, p < 0.001) and inotropes (37.1% vs 3.7%, p < 0.001) compared with neonates without AKI. In multivariable-adjusted models, increased AKI risk was observed with antenatal indomethacin doses received within 24 to 48 hours (HR, 1.6; 95% CI, 1.28–1.94; p = 0.036) and CONCLUSIONSExtended risk of AKI with antenatal indomethacin deserves clinical attention among this population at an already increased AKI risk. |
| Databáze: | OpenAIRE |
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