ConTra v2: a tool to identify transcription factor binding sites across species, update 2011
| Autor: | Pieter De Bleser, Bart Hooghe, Frans van Roy, Paco Hulpiau, Stefan Broos, Jeroen Galle |
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| Rok vydání: | 2011 |
| Předmět: |
EXPRESSION
Untranslated region MICRORNAS PROMOTER Molecular Sequence Data Computational biology Biology Genome RNAS INTRON Genetics Humans Regulatory Elements Transcriptional Binding site Promoter Regions Genetic Gene Transcription factor Regulation of gene expression GENE-REGULATION Binding Sites IDENTIFICATION Base Sequence Intron Biology and Life Sciences Articles DNA binding site CELLS Software Transcription Factors |
| Zdroj: | Nucleic Acids Research NUCLEIC ACIDS RESEARCH |
| ISSN: | 1362-4962 0305-1048 |
| Popis: | Transcription factors are important gene regulators with distinctive roles in development, cell signaling and cell cycling, and they have been associated with many diseases. The ConTra v2 web server allows easy visualization and exploration of predicted transcription factor binding sites in any genomic region surrounding coding or non-coding genes. In this new version, users can choose from nine reference organisms ranging from human to yeast. ConTra v2 can analyze promoter regions, 5 0 -UTRs, 3 0 -UTRs and introns or any other genomic region of interest. Hundreds of position weight matrices are available to choose from, but the user can also upload any other matrices for detecting specific binding sites. A typical analysis is run in four simple steps of choosing the gene, the transcript, the region of interest and then selecting one or more transcription factor binding sites. The ConTra v2 web server is freely available at http://bioit.dmbr.ugent.be/ contrav2/index.php. |
| Databáze: | OpenAIRE |
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