Clonal Proliferation of Lymphoid and Myeloid Progenitor Cells in Patients with Hematological Abnormalities
| Autor: | Roma Rokicka-Milewska, Krystyna Kolakowska-Polubiec, Andrzej Górski, Kazimierz Madaliński, Joanna Litwin |
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| Rok vydání: | 1979 |
| Předmět: |
Adult
Myeloid Cell division Lymphoproliferative disorders Colony-Forming Units Assay Bone Marrow hemic and lymphatic diseases Precursor cell medicine Humans Lymphocytes Aplastic anemia Child Aged business.industry Hematology General Medicine Middle Aged medicine.disease Hematologic Diseases Hodgkin Disease Lymphoproliferative Disorders Clone Cells Hematopoiesis Leukemia Lymphoid Haematopoiesis medicine.anatomical_structure Immunology Cytomegalovirus Infections Lymphoid Progenitor Cells Bone marrow business Cell Division |
| Zdroj: | Vox Sanguinis. 37:84-88 |
| ISSN: | 1423-0410 0042-9007 |
| DOI: | 10.1159/000466891 |
| Popis: | Myeloid and lymphoid stem cell colony formation (GM-CFU) and L-CFU) was studied in patients with lymphoproliferative diseases, aplastic anemia and other hematological abnormalities. Most patients with acute lymphatic leukemia had low number of L-CFU with decreased or normal GM-CFU, while in Hodgkin's disease and chronic lymphatic leukemia L-CFU growth was very poor with only minor abnormalities of GM-CFU formation. Aplastic anemia was characterized by a decreased GM-CFU and normal L-CFU. Coculture studies suggested that a diminished colony formation may be linked to circulating lymphocytes that inhibit L-CFU as well as the reduction in number of precursor cells. |
| Databáze: | OpenAIRE |
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