Effects of endoscopic variceal sclerotherapy on azygos vein blood flow and systemic haemodynamics
| Autor: | Makoto Okumura, Masanori Yokoyama, Katsuhiko Kubara, Nobuo Akiyoshi, Tetsuhiro Kim, Hiroshi Shijo, Kazuhiro Ota, Hiroshi Kokawa, Hideo Tokumitsu |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Cardiac index Hemodynamics Esophageal and Gastric Varices Gastroenterology Bile Acids and Salts Internal medicine Sclerotherapy medicine Humans Splanchnic Circulation Aged Blood Volume Hepatology business.industry Endoscopy Blood flow Middle Aged medicine.anatomical_structure Liver Regional Blood Flow Azygos Vein Hyperdynamic circulation cardiovascular system Vascular resistance Cardiology Female Portosystemic shunt Azygos vein business |
| Zdroj: | Journal of gastroenterology and hepatology. 11(8) |
| ISSN: | 0815-9319 |
| Popis: | The present study was designed to determine the systemic haemodynamic effects of obliterating oesophageal varices by endoscopic sclerotherapy. We evaluated systemic and splanchnic haemodynamics before and after the first course of sclerotherapy in cirrhotic patients. The baseline cardiac index was significantly correlated with baseline azygos vein blood flow (r = 0.64; P < 0.01) and the azygos vein blood flow and cardiac index significantly decreased (-33% and -16%, respectively; P < 0.01) following sclerotherapy. The systemic vascular resistance index was also increased significantly (+ 20%; P < 0.01) in these patients. Moreover, the per cent change in azygos vein blood flow was directly correlated with that of the cardiac index (r = 0.51; P < 0.03). We conclude from these findings that the obliteration of portosystemic collaterals by sclerotherapy significantly reverses hyperdynamic circulation in such patients via a decrease in cardiac preload. The blood flow of the portosystemic shunt per se is a leading contributor to the hyperdynamic circulation observed in patients with well-developed portal systemic collateral vessels. |
| Databáze: | OpenAIRE |
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