Expression of Zkrml2, a homologue of the Krml1/val segmentation gene, during embryonic patterning of the zebrafish (Danio rerio)

Autor:	Sabine P. Cordes, Pascal Haffter, Annette Kirn, Mara Schvarzstein
Rok vydání:	1999
Předmět:	Male Embryology Embryo Nonmammalian Mice Mesencephalon Somitogenesis Morphogenesis Zebrafish Neurons Oncogene Proteins Genetics Regulation of gene expression biology Myogenesis Chromosome Mapping Gene Expression Regulation Developmental Cell biology DNA-Binding Proteins medicine.anatomical_structure Somites Organ Specificity Proto-Oncogene Proteins c-maf Female animal structures MafB Transcription Factor Molecular Sequence Data Danio Dermomyotome Nerve Tissue Proteins Avian Proteins Species Specificity Proto-Oncogene Proteins medicine Animals Amino Acid Sequence Leucine Zippers Sequence Homology Amino Acid fungi Zebrafish Proteins biology.organism_classification Rhombencephalon Segmentation gene Somite Genes Mutagenesis Maf Transcription Factors Sequence Alignment Transcription Factors Developmental Biology
Zdroj:	Mechanisms of Development. 80(2):223-226
ISSN:	0925-4773
DOI:	10.1016/s0925-4773(98)00220-2
Popis:	We have identified Zkrml2, a novel homologue of the segmentation gene Krml/val in zebrafish (Danio rerio). Zkrml2 shows 72% and 92% identity in its basic leucine zipper domain with mouse Krml1 and zebrafish val, respectively. Zkrml2 is expressed coincident with MyoD throughout the somites starting at the three somite stage, becomes restricted to the dermomyotome, and subsequently disappears. Transient expression is also detected in the reticulospinal and oculomotor neurons. Zkrml2 maps to the Oregon linkage group 11 (Boston Linkage group 14) with no mapped zebrafish mutations nearby.
Databáze:	OpenAIRE
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