Gastrointestinal bleeding and endoscopic findings in critically and non‐critically ill patients with corona virus disease 2019 (COVID‐19): results from Lean European Open Survey on SARS‐CoV‐2 (LEOSS) and COKA registries
| Autor: | Christian Degenhardt, Johanna Classen, Siri Göpel, Georg Braun, Anna Muzalyova, Frank Hanses, Stefan Borgmann, Melanie Stecher, Jan Rupp, Christiane Piepel, Ingo Voigt, Maria Rüthrich, Christine Dhillon, Christoph Römmele, Stephan Zellmer, Carolin Jakob, Helmut Messmann, Lisa Pilgram, Alanna Ebigbo, Johanna Erber, Kai Wille, Lorenz Walter, Martin Hower |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
critically ill Disease Comorbidity Severity of Illness Index Endoscopy Gastrointestinal SARS‐CoV‐2 law.invention LEOSS law Registries Child Aged 80 and over medicine.diagnostic_test Incidence (epidemiology) Gastroenterology Middle Aged Intensive care unit Europe Hospitalization Intensive Care Units Oncology Child Preschool Gastroesophageal Reflux population characteristics Female Original Article Gastrointestinal Hemorrhage Adult Gastrointestinal bleeding medicine.medical_specialty Peptic Ulcer Coronavirus disease 2019 (COVID-19) Adolescent Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Critical Illness Young Adult COVID‐19 Internal medicine parasitic diseases medicine Humans ddc:610 Aged Diverticular Diseases business.industry Reflux Anticoagulants COVID-19 Infant Endoscopy medicine.disease GI bleeding business human activities |
| Zdroj: | United European Gastroenterology Journal |
| Popis: | Background Corona virus disease 2019 (COVID‐19) patients are at increased risk for thromboembolic events. It is unclear whether the risk for gastrointestinal (GI) bleeding is also increased. Methods We considered 4128 COVID‐19 patients enrolled in the Lean European Open Survey on SARS‐CoV‐2 (LEOSS) registry. The association between occurrence of GI bleeding and comorbidities as well as medication were examined. In addition, 1216 patients from COKA registry were analyzed focusing on endoscopy diagnostic findings. Results A cumulative number of 97 patients (1.8%) with GI bleeding were identified in the LEOSS registry and COKA registry. Of 4128 patients from the LEOSS registry, 66 patients (1.6%) had a GI bleeding. The rate of GI bleeding in patients with intensive care unit (ICU) admission was 4.5%. The use of therapeutic dose of anticoagulants showed a significant association with the increased incidence of bleeding in the critical phase of disease. The Charlson comorbidity index and the COVID‐19 severity index were significantly higher in the group of patients with GI bleeding than in the group of patients without GI bleeding (5.83 (SD = 2.93) vs. 3.66 (SD = 3.06), p |
| Databáze: | OpenAIRE |
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