Tcf21+mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration
| Autor: | Meena Sukhwani, Qianyi Ma, Jourdan Clements, Michael Czerwinski, Yu-chi Shen, Haolin Chen, Hailey Larose, Lindsay Moritz, Caleb Sultan, Jun Li, Michelle D. Tallquist, Adrienne Niederriter Shami, Jason R. Spence, Gabriel L. Manske, Saher Sue Hammoud, Kyle E. Orwig, Xianing Zheng |
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| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
education.field_of_study Cell type Somatic cell Regeneration (biology) Population Mesenchymal stem cell Biology Germline Cell biology 03 medical and health sciences 0302 clinical medicine Progenitor cell education 030217 neurology & neurosurgery Tissue homeostasis 030304 developmental biology |
| Popis: | SummaryTesticular development and function relies on interactions between somatic cells and the germline, but similar to other organs, regenerative capacity decline in aging and disease. Whether the adult testis maintains a reserve progenitor population with repair or regenerative capacity remains uncertain. Here, we characterized a recently identified mouse testis interstitial population expressing the transcription factor Tcf21. We found that Tcf21+cells are bipotential somatic progenitors present in fetal testis and ovary, maintain adult testis homeostasis during aging, and act as reserve somatic progenitors following injury.In vitro, Tcf21+cells are multipotent mesenchymal progenitors which form multiple somatic lineages including Leydig and myoid cells. Additionally, Tcf21+cells resemble resident fibroblast populations reported in other organs having roles in tissue homeostasis, fibrosis, and regeneration. Our findings reveal that the testis, like other organs, maintains multipotent mesenchymal progenitors that can be leveraged in development of future therapies for hypoandrogenism and/or infertility.HighlightsMultipotent Tcf21+MPs can differentiate into somatic testis cell typesTcf21+cells contribute to testis and ovary somatic cells during gonadal developmentTcf21+cells replenish somatic cells of the aging testis and in response to tissue injuryTestis Tcf21 cells resemble resident fibroblast populations in multiple organs |
| Databáze: | OpenAIRE |
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