Asymptomatic deer excrete infectious prions in feces
| Autor: | Tracey M. Sirochman, Azucena Lemus, Lisa L. Wolfe, David V. Glidden, Christina G.S. Palmer, Stanley B. Prusiner, Michael W. Miller, Gültekin Tamgüney, Stephen J. DeArmond |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Time Factors
PrPSc Proteins animal diseases Administration Oral Neurodegenerative Odocoileus Transgenic Feces Mice 0302 clinical medicine Chronic Infectivity 0303 health sciences Multidisciplinary Infectious dose Brain 3. Good health Infectious Diseases Neurological Administration Wasting Disease Chronic Biological Assay medicine.symptom Horizontal transmission Oral Wasting Disease General Science & Technology Intraventricular Mice Transgenic Biology Asymptomatic Article Injections 03 medical and health sciences Rare Diseases parasitic diseases medicine Animals 030304 developmental biology Injections Intraventricular Deer Neurosciences Transmissible Spongiform Encephalopathy (TSE) Chronic wasting disease medicine.disease biology.organism_classification Virology Brain Disorders Emerging Infectious Diseases Good Health and Well Being 030217 neurology & neurosurgery |
| Zdroj: | Nature Nature, vol 461, iss 7263 Tamgüney, G; Miller, MW; Wolfe, LL; Sirochman, TM; Glidden, DV; Palmer, C; et al.(2009). Asymptomatic deer excrete infectious prions in faeces. Nature, 461(7263), 529-532. doi: 10.1038/nature08289. UCSF: Retrieved from: http://www.escholarship.org/uc/item/1jz6m94h |
| ISSN: | 1476-4687 0028-0836 |
| Popis: | Infectious prion diseasesĝ€"scrapie of sheep and chronic wasting disease (CWD) of several species in the deer familyĝ€" are transmitted naturally within affected host populations. Although several possible sources of contagion have been identified in excretions and secretions from symptomatic animals, the biological importance of these sources in sustaining epidemics remains unclear. Here we show that asymptomatic CWD-infected mule deer (Odocoileus hemionus) excrete CWD prions in their faeces long before they develop clinical signs of prion disease. Intracerebral inoculation of irradiated deer faeces into transgenic mice overexpressing cervid prion protein (PrP) revealed infectivity in 14 of 15 faecal samples collected from five deer at 7ĝ€"11 months before the onset of neurological disease. Although prion concentrations in deer faeces were considerably lower than in brain tissue from the same deer collected at the end of the disease, the estimated total infectious dose excreted in faeces by an infected deer over the disease course may approximate the total contained in a brain. Prolonged faecal prion excretion by infected deer provides a plausible natural mechanism that might explain the high incidence and efficient horizontal transmission of CWD within deer herds, as well as prion transmission among other susceptible cervids. © 2009 Macmillan Publishers Limited. All rights reserved. |
| Databáze: | OpenAIRE |
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