Application of fibrin in drug technology: Achievements and perspectives
| Autor: | Justyna Wilińska, A. Turek, Aleksandra Borecka, Jakub Rech |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
Drug 0303 health sciences drug technology biology Chemistry media_common.quotation_subject Pharmacology Fibrin 03 medical and health sciences 0302 clinical medicine Infectious Diseases 030220 oncology & carcinogenesis drug delivery biology.protein Medicine fibrin 030304 developmental biology media_common |
| Zdroj: | Postępy Higieny i Medycyny Doświadczalnej, Vol 74, Pp 322-330 (2020) |
| ISSN: | 1732-2693 0032-5449 |
| Popis: | In recent years, fibrin has been successfully used as a polymer drug delivery carrier. Passive properties of fibrin provide parenteral and local delivery of drug substances in controlled and prolonged manner and also tissue support, gluing and sealing. Fibrin also has hemostatic and proangiogenic effects. Discs, films, gels, beads and nanoparticles are among the most commonly proposed and used fibrin-based formulations. It is routinely obtained from fibrinogen and thrombin. Fibrin formulation methods are solution casting, dual syringe systems and emulsification. All fibrin formulations become gel after administration and water absorption. Biodegradation and biocompatibility are important advantages of fibrin, which make it possible to implant a formulation without the need to remove the carrier from the body after the drug is released. Fibrin-based drug delivery systems are proposed and applied in the treatment of wounds, infections and cancerous diseases. |
| Databáze: | OpenAIRE |
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