Hypothalamic and septal neuronal responses to iontophoretic application of salicylate in rats
| Autor: | E. Rozkowska-Ruttimann, A.L. Beckman |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Male
Serotonin medicine.medical_specialty Hypothalamus Anterior hypothalamic area Inhibitory postsynaptic potential Body Temperature Stereotaxic Techniques Norepinephrine (medication) Norepinephrine Cellular and Molecular Neuroscience chemistry.chemical_compound Internal medicine medicine Animals Sodium salicylate Neurons Pharmacology Iontophoresis Acetylcholine Salicylates Rats Endocrinology nervous system chemistry Excitatory postsynaptic potential Septal Nuclei Septum Pellucidum medicine.drug |
| Zdroj: | Neuropharmacology. 13:393-398 |
| ISSN: | 0028-3908 |
| DOI: | 10.1016/0028-3908(74)90121-x |
| Popis: | Iontophoretic application of sodium salicylate to neurones in the septum and preoptic/ anterior hypothalamic area in afebrile rats resulted in excitation of the majority of drug-sensitive cells tested. The excitatory and inhibitory responses of neurones to salicylate were similar to those produced by comparable application of acetylcholine, 5-hydroxytryptamine, and norepinephrine. Tests with preoptic/anterior hypothalamic temperature-sensitive neurones showed that the majority of warm-sensitive cells was excited by salicylate. The responses of these presumed thermoregulatory neurones to salicylate are compatible with, and may therefore be involved in producing, the augmented heat-loss which is characteristic of salicylate-induced defervescence from pyrogen fever. |
| Databáze: | OpenAIRE |
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