AMPA receptor GluR2, but not GluR1, subunit deletion impairs emotional response conditioning in mice
| Autor: | Stuart L. Rulten, Daniel Zamanillo, Claire I. Dixon, David N. Stephens, H.V. Morris, Andy N. Mead, Lynne V. Mayne |
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| Rok vydání: | 2006 |
| Předmět: |
Conditioned emotional response
Male medicine.medical_specialty AMPA receptor Stimulus (physiology) In Vitro Techniques Amygdala Behavioral Neuroscience Mice Internal medicine medicine Avoidance Learning Animals GRIA2 Affective Symptoms Receptors AMPA Freezing Reaction Cataleptic Maze Learning GRIA1 Mice Knockout Analysis of Variance biology Behavior Animal Glutamate receptor Classical conditioning Mice Inbred C57BL medicine.anatomical_structure Endocrinology biology.protein Conditioning Operant Psychology Neuroscience |
| Zdroj: | Behavioral neuroscience. 120(2) |
| ISSN: | 0735-7044 |
| Popis: | Deletions of gria1 or gria2 genes encoding alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic-acid-receptor subunits differ in their effects on appetitive conditioning. The authors investigated whether similar differences would occur in an aversive conditioning test. The ability of a discrete stimulus paired with footshock to subsequently inhibit food-maintained operant responding (conditioned emotional response) was examined in mice with deletions of gria1 or gria2 genes. Whereas gria1 knockout (KO) mice performed normally compared with wild-type (WT) controls, gria2 KO mice displayed no reduction in response rates when the shock-paired stimulus was presented. Nevertheless, gria2 KOs displayed evidence of freezing in a footshock-paired context, indicating that aversive learning could occur. In addition, gria1 KO mice showed some evidence of increased anxiety, and gria2 KOs showed reduced anxiety, in the elevated plus-maze. (PsycINFO Database Record (c) 2012 APA, all rights reserved) |
| Databáze: | OpenAIRE |
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