Subclinical Mastitis in a European Multicenter Cohort: Prevalence, Impact on Human Milk (HM) Composition, and Association with Infant HM Intake and Growth

Autor: Magnus Domellöf, Jean-Charles Picaud, Isam Al-Jashi, Michael Affolter, Kirsti Haaland, Eurídice Castañeda-Gutiérrez, Silvia Maria Stoicescu, Maria Jose Costeira, Sagar K. Thakkar, Stéphane Dubascoux, Giovanna Marchini, Tom Stiris, Carlos Antonio De Castro, Massimo Agosti, Maria Gorett Silva, Mireilla Vanpee, Cecilia Martínez-Costa, Francesca Giuffrida, Almerinda Barroso Pereira, Claude Billeaud, Irma Silva-Zolezzi, Tinu Mary Samuel, Thameur Rakza
Přispěvatelé: Nestlé Institute of Health Sciences SA [Lausanne, Switzerland], CHU de Bordeaux Pellegrin [Bordeaux], Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), AUTRES, Medicine Faculty, Titu Maiorescu University, City Bucharest, Romania., Hospital de São João [Porto], Karolinska University Hospital [Stockholm], Hôpital Jeanne de Flandres, Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Oslo University Hospital [Oslo], Polizu Hospital, Universitat de València (UV), Umeå University
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nutrients
Volume 12
Issue 1
Nutrients, 2020, 12 (1), ⟨10.3390/nu12010105⟩
Nutrients, Vol 12, Iss 1, p 105 (2019)
ISSN: 2072-6643
DOI: 10.3390/nu12010105
Popis: Background: Subclinical mastitis (SCM) is an inflammatory condition of the mammary gland. We examined the effects of SCM on human milk (HM) composition, infant growth, and HM intake in a mother&ndash
infant cohort from seven European countries. Methods: HM samples were obtained from 305 mothers at 2, 17, 30, 60, 90, and 120 days postpartum. SCM status was assessed using HM Sodium (Na): Potassium (K) ratio >
0.6. Levels of different macro- and micronutrients were analyzed in HM. Results: SCM prevalence in the first month of lactation was 35.4%. Mean gestational age at delivery was lower and birth by C-section higher in SCM mothers (p &le
0.001). HM concentrations of lactose, DHA, linolenic acid, calcium, and phosphorous (p <
0.05 for all) was lower, while total protein, alpha-lactalbumin, lactoferrin, albumin, arachidonic acid to DHA ratio, n-6 to n-3 ratio and minerals (iron, selenium, manganese, zinc, and copper) were higher (p <
0.001 for all) in mothers with SCM. There were no differences in infant growth and HM intake between non-SCM and SCM groups. Conclusion: We document, for the first time, in a large European standardized and longitudinal study, a high prevalence of SCM in early lactation and demonstrate that SCM is associated with significant changes in the macro- and micronutrient composition of HM. Future studies exploring the relation of SCM with breastfeeding behaviors and developmental outcomes are warranted.
Databáze: OpenAIRE
Externí odkaz: