Acute life-threatening extrinsic allergic alveolitis in a paint controller
| Autor: | D. Thorn, Nikhil Yawalkar, U.-C. Steiner, Catherine Tomicic, C. K. Huynh, Brigitta Danuser, Gilles Bieler |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
business.industry Public Health Environmental and Occupational Health Extrinsic Allergic Alveolitis Context (language use) Air Pollutants Occupational medicine.disease Diagnosis Differential Occupational Diseases chemistry.chemical_compound chemistry Occupational Exposure Paint Immunology Humans Medicine Female Hexamethylene diisocyanate business Cyanates Hypersensitivity pneumonitis Alveolitis Extrinsic Allergic Isocyanates |
| Zdroj: | Bieler, G; Thorn, D; Huynh, C K; Tomicic, C; Steiner, U-C; Yawalkar, N; Danuser, B (2011). Acute life-threatening extrinsic allergic alveolitis in a paint controller. Occupational medicine, 61(6), pp. 440-2. Oxford: Oxford University Press 10.1093/occmed/kqr057 |
| DOI: | 10.7892/boris.7086 |
| Popis: | Background Occupational diisocyanate-induced extrinsic allergic alveolitis (EAA) is a rare and probably underestimated diagnosis. Two acute occupational EAA cases have been described in this context, but neither of them concerned hexamethylene diisocyanate (HDI) exposure. Aims To investigate the cause of a life-threatening EAA arising at work in a healthy 30-year-old female paint quality controller. Methods Occupational medical assessment, workplace evaluation, airborne and biological monitoring and immunodermatological tests. Results Diagnosis of EAA relied on congruent clinical and radiological information, confirmed occupational HDI exposure and positive IgG antibodies and patch tests. The patient worked in a small laboratory for 7 years, only occasionally using HDI-containing hardeners. While working with HDI for 6 h, she developed breathlessness, rapidly progressing to severe respiratory failure. Workplace HDI airborne exposure values ranged from undetectable levels to 4.25 p.p.b. Biological monitoring of urinary hexamethylene diamine in co-workers ranged from |
| Databáze: | OpenAIRE |
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