A Pilot Study on the Effects of Sodium Oxybate on Sleep Architecture and Daytime Alertness in Narcolepsy
| Autor: | Mortimer Mamelak, Ruzica Ristanovic, Jed Black, Jacques Montplaisir |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Cataplexy Sodium Oxybate Polysomnography Rapid eye movement sleep Administration Oral Pilot Projects Drug Administration Schedule Physiology (medical) medicine Humans Wakefulness Narcolepsy Sleep disorder Dose-Response Relationship Drug medicine.diagnostic_test Epworth Sleepiness Scale Middle Aged medicine.disease Circadian Rhythm Alertness Delta Rhythm Anesthesia Central Nervous System Stimulants Drug Therapy Combination Female Sleep Stages Neurology (clinical) medicine.symptom Psychology Adjuvants Anesthesia |
| Zdroj: | Sleep. 27:1327-1334 |
| ISSN: | 1550-9109 0161-8105 |
| DOI: | 10.1093/sleep/27.7.1327 |
| Popis: | Study objectives To measure the effect of nocturnal sodium oxybate administration on sleep architecture in patients with narcolepsy. Design Open-label study. Setting Four accredited sleep clinics. Participants 25 adult patients with narcolepsy-cataplexy. Interventions Patients were weaned from previously used anticataplectic medications and administered increasing nightly doses of sodium oxybate over a 10-week period: 4.5 g for 4 weeks, 6 g for 2 weeks, 7.5 g for 2 weeks, and 9 g for 2 weeks. The effect of sodium oxybate was measured using nocturnal polysomnograms, the Epworth Sleepiness Scale, the Maintenance of Wakefulness Test, and a narcolepsy symptoms questionnaire. Results The nightly administration of sodium oxybate produced dose-related increases in slow-wave sleep and delta power, rapid eye movement sleep increased initially and then decreased in a dose-related manner, nocturnal awakenings decreased, and daytime sleep latency increased. Significant improvements in daytime symptoms were measured by the Maintenance of Wakefulness Test, the Epworth Sleepiness Scale, and the narcolepsy symptom questionnaire. Conclusions Nocturnal administration of sodium oxybate in patients with narcolepsy produces significant improvements in sleep architecture, which coincide with significant improvements in daytime functioning. |
| Databáze: | OpenAIRE |
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