Individual and combined effects of the infrared, visible, and ultraviolet light components of solar radiation on damage biomarkers in human skin cells
| Autor: | D J Rawlings, Catherine A Bonn, Mark A. Birch-Machin, Bhaven Chavan, Eyman Rashdan, Laura Hudson |
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| Rok vydání: | 2020 |
| Předmět: |
Keratinocytes
0301 basic medicine Light photoaging Infrared Rays Ultraviolet Rays Photoaging Human skin medicine.disease_cause DNA Mitochondrial Biochemistry 03 medical and health sciences 0302 clinical medicine Genetics medicine Ultraviolet light Humans oxidative stress Molecular Biology Cells Cultured Research Articles Skin Sunlight integumentary system Chemistry photodamage DNA Fibroblasts medicine.disease photoprotection 030104 developmental biology Photoprotection Biophysics Comet Assay sunlight Skin cancer Reactive Oxygen Species Biomarkers 030217 neurology & neurosurgery Oxidative stress Ultraviolet Research Article Biotechnology |
| Zdroj: | The FASEB Journal |
| ISSN: | 1530-6860 0892-6638 |
| Popis: | The ability of solar ultraviolet (UV) to induce skin cancer and photoaging is well recognized. The effect of the infrared (IR) and visible light (Vis) components of solar radiation on skin and their interaction with UV is less well known. This study compared the effects of physiologically relevant doses of complete (UV + Vis + IR) solar‐simulated light and its individual components on matched primary dermal fibroblasts and epidermal keratinocytes from human donors on three biomarkers of cellular damage (reactive oxygen species (ROS) generation, mitochondrial DNA (mtDNA), and nuclear DNA (nDNA) damage). There was a greater induction of ROS, mtDNA, and nDNA damage with the inclusion of the visible and IR components of solar‐simulated light in primary fibroblast cells compared to primary keratinocytes (P |
| Databáze: | OpenAIRE |
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