Long-term depression in cerebellar Purkinje neurons results from coincidence of nitric oxide and depolarization-induced Ca2+ transients
| Autor: | Joseph P. Y. Kao, Roger Y. Tsien, Paul F. Keitz, Lewis R. Makings, Varda Lev-Ram |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Cerebellum
Neuroscience(all) Action Potentials Parallel fiber Arginine Nitric Oxide Nitroarginine Synaptic Transmission Nitric oxide chemistry.chemical_compound Purkinje Cells Postsynaptic potential medicine Animals Long-term depression Carbon Monoxide Neuronal Plasticity Photolysis Chemistry General Neuroscience Depolarization Rats medicine.anatomical_structure Oxyhemoglobins Biophysics Calcium Neuroscience Intracellular |
| Zdroj: | Neuron. (2):407-415 |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/0896-6273(95)90044-6 |
| Popis: | The role of nitric oxide (NO) in the induction of longterm depression (LTD) in the cerebellum was explored using a new, organic, membrane-impermeant form of caged NO. NO photolytically released inside Purkinje neurons mimicked parallel fiber (PF) activity in synergizing with brief postsynaptic depolarization to induce LTD. Such LTD required a delay of |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|