Hemodynamic support with the pulsatile catheter pump in a sheep model of acute heart failure
| Autor: | Weijun Wang, Min Tang, Qing Ye, Chang-Zhi Chen, Zhicheng Li, Y. John Gu, Shao-Fei Cheng, Xiao-Gang Zhao, Gerhard Rakhorst |
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| Rok vydání: | 2006 |
| Předmět: |
Cardiac output
Mean arterial pressure medicine.medical_specialty Biomedical Engineering Medicine (miscellaneous) Hemodynamics Bioengineering Blood Pressure Biomaterials Internal medicine medicine.artery medicine Animals Assisted Circulation Cardiac Output Coronary sinus Heart Failure Sheep business.industry General Medicine Equipment Design medicine.disease Disease Models Animal Blood pressure Heart failure Pulsatile Flow Pulmonary artery Acute Disease Cardiology business Perfusion |
| Zdroj: | Artificial organs. 30(11) |
| ISSN: | 0160-564X |
| Popis: | This study was aimed to mimic clinical heart failure (HF) conditions and to assess the effect of pulsatilecatheter (PUCA) pump support on hemodynamics and tissue perfusion in a sheep model of acute HF. In 14 sheep, HF was induced by partial occluding the middle left circumflex coronary artery combined with pacemaker-induced tachycardia. PUCA pump was then activated to support the HF for 3 h. Hemodynamic parameters were recorded at baseline, HF, and then every 30 min during experiments. Blood samples were taken in carotid artery (CA), pulmonary artery (PA), and coronary sinus (CS) for the determination of oxygen saturation (SO2) and lactate concentration as markers of tissue perfusion. Results showed that HF model was induced successfully in 10 sheep and failed in four sheep due to refractory ventricular fibrillation. PUCA pump support was successful in seven out of 10 sheep for 3 h. Three cases failed due to technical problems. After HF (n = 10), cardiac output (CO) was decreased from 3.7 +/- 0.5 to 2.0 +/- 0.5 L/min (P |
| Databáze: | OpenAIRE |
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