Dynamics of structural reversal in Bruch’s membrane opening-based morphometrics after glaucoma drainage device surgery

Autor: Caroline Gietzelt, Corinna von Goscinski, Philip Enders, Friederike Schaub, Claus Cursiefen, Ludwig M. Heindl, Manuel M. Hermann, Julia Lemke, Thomas S. Dietlein
Rok vydání: 2020
Předmět:
Male
Retinal Ganglion Cells
0301 basic medicine
Intraocular pressure
genetic structures
medicine.medical_treatment
Visual Acuity
Nerve fiber layer
Glaucoma
Bruch's membrane
chemistry.chemical_compound
Nerve Fibers
0302 clinical medicine
Trabeculectomy
Child
Glaucoma Drainage Implants
Aged
80 and over
Middle Aged
Glaucoma drainage device
Sensory Systems
medicine.anatomical_structure
Optic nerve
Female
Glaucoma
Open-Angle
Tomography
Optical Coherence
Adult
medicine.medical_specialty
Adolescent
Optic Disk
Prosthesis Implantation
Tonometry
Ocular
03 medical and health sciences
Cellular and Molecular Neuroscience
medicine
Humans
Intraocular Pressure
Aged
Retrospective Studies
business.industry
Retinal
medicine.disease
eye diseases
Surgery
Ophthalmology
Cross-Sectional Studies
030104 developmental biology
ROC Curve
chemistry
030221 ophthalmology & optometry
Visual Field Tests
Bruch Membrane
sense organs
Visual Fields
business
Follow-Up Studies
Zdroj: Graefe's Archive for Clinical and Experimental Ophthalmology. 258:1227-1236
ISSN: 1435-702X
0721-832X
DOI: 10.1007/s00417-020-04621-y
Popis: Structural reversal of disc cupping is a known phenomenon after trabeculectomy. The aim of this retrospective, longitudinal, cross-sectional analysis was to evaluate the postoperative dynamics of Bruch's membrane opening-based morphometrics of the optic nerve head following glaucoma drainage device surgery.Forty-three eyes, treated by glaucoma drainage device surgery, were included in the study. Individual changes in the spectral domain optic coherence tomography (SD-OCT) parameters Bruch's membrane opening minimum rim width (BMO-MRW), Bruch's membrane opening minimum rim area (BMO-MRA) and peripapillary retinal nerve fiber layer (RNFL) thickness as well as mean defect in 30-2 perimetry were analyzed. Changes were correlated to postoperative intraocular pressure levels over time. Available follow-up visits were aggregated and grouped into a short-term follow-up (20 to 180 days after surgery), a midterm follow-up (181 to 360 days after surgery) and a long-term follow-up (more than 360 days after surgery).In short-term follow-up, BMO-MRW and BMO-MRA increased significantly (p = 0.034). This increase correlated negatively with the intraocular pressure at the time of the follow-up (Pearson's rho = - 0.49; p = 0.039). From 6 months after surgery on, there was no statistically significant change in BMO-MRW and BMO-MRA (p = 0.207). RNFL thickness and mean defect of 30-2 perimetry showed no significant changes after GDD implantation (p = 0.189).Lowering of intraocular pressure by glaucoma drainage device surgery leads to an increase of Bruch's membrane opening based parameters in the first 6 months after surgery. These changes have to be taken into account when evaluating patients' longitudinal follow-up after glaucoma drainage device implantation.
Databáze: OpenAIRE
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