Celiac disease and reproductive failures: An update on pathogenic mechanisms
| Autor: | Nicoletta Di Simone, Roberta Castellani, Giovanni Scambia, Chiara Tersigni, Silvia D'Ippolito, Monia Specchia, Matteo Gratta |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Abortion Habitual Immunology Autoimmunity Inflammation Disease medicine.disease_cause Intestinal malabsorption 03 medical and health sciences 0302 clinical medicine Pregnancy Tissue damage medicine Animals Humans Immunology and Allergy Reproductive failures Fetal Growth Retardation 030219 obstetrics & reproductive medicine Obstetric disorders business.industry Pregnancy Outcome Obstetrics and Gynecology medicine.disease Settore MED/40 - GINECOLOGIA E OSTETRICIA 030104 developmental biology Reproductive Medicine Female medicine.symptom business Infertility Female celiac disease |
| Zdroj: | American Journal of Reproductive Immunology. 85 |
| ISSN: | 1600-0897 1046-7408 |
| DOI: | 10.1111/aji.13334 |
| Popis: | Celiac disease (CD) is an autoimmune disorder that occurs in genetically predisposed people in which the ingestion of gluten leads to damage in the small intestine that clinically presents with malabsorption-related symptoms. CD can also be the underlying cause of several non-gastrointestinal symptoms. This review summarizes evidence on the relationship between CD and gynecological/obstetric disorders like reproductive failures. Although much has been reported on such a linkage, the pathogenic mechanisms remain unclear, especially those underlying extra-gastrointestinal clinical manifestations. Studies conducted on celiac subjects presenting gynecological/obstetric disorders have pointed to intestinal malabsorption, coagulation alterations, immune-mediated tissue damage, and endometrial inflammation as the main responsible pathogenic mechanisms. Currently, however, the knowledge of such mechanisms is insufficient, and further studies are needed to gain a more thorough understanding of the matter. |
| Databáze: | OpenAIRE |
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