Insulin independence and normalization of oral glucose tolerance test after islet cell allotransplantation

Autor: Jacques Philippe, C Becker, Philippe Morel, Leo Buhler, A. Caulfield, B. Fournier, Nathalie Cretin
Jazyk: angličtina
Rok vydání: 2001
Předmět:
Nephrology
Blood Glucose
Time Factors
endocrine system diseases
medicine.medical_treatment
Islets of Langerhans Transplantation
Gastroenterology
Diabetes Mellitus
Type 1/blood/surgery
chemistry.chemical_compound
Reference Values
Insulin
ddc:616
Glucose tolerance test
geography.geographical_feature_category
Blood Glucose/drug effects/metabolism
medicine.diagnostic_test
C-Peptide
ddc:617
C-peptide
Islet
Islets of Langerhans Transplantation/physiology
medicine.anatomical_structure
Insulin/therapeutic use
C-Peptide/blood
Female
Glucagon/diagnostic use
Pancreas
Adult
medicine.medical_specialty
endocrine system
Hypoglycemic Agents/therapeutic use
ddc:616.0757
Internal medicine
Diabetes mellitus
medicine
Hypoglycemic Agents
Humans
Transplantation
Homologous
geography
Transplantation
business.industry
Glucose Tolerance Test
medicine.disease
Glucagon
Surgery
Diabetes Mellitus
Type 1
chemistry
business
Allotransplantation
Follow-Up Studies
Zdroj: Transplant International, Vol. 14, No 5 (2001) pp. 343-5
ISSN: 0934-0874
Popis: To achieve permanent normoglycemia in patients with type I diabetes, it is necessary to renew the insulin-producing beta-cells by transplantation of either a vascularized pancreatic graft or isolated islets of Langerhans. Presently, about 10% of patients with type I diabetes undergoing islet allotransplantation achieve insulin independence; however, glucose intolerance remains in the majority of cases. We report a case of long-term insulin independence after islet allotransplantation in a type I diabetic patient. Three years after islet transplantation, the patient remains insulin-independent with a normal oral glucose tolerance test (OGTT). The patient therefore no longer meets the World Health Organization criteria for the diagnosis of diabetes mellitus and demonstrates that islet transplantation can cure diabetes in type I diabetic patients.
Databáze: OpenAIRE
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