Gene drives may be the next step towards sustainable control of malaria
| Autor: | Robyn R. Raban, Omar S. Akbari |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Mosquito Control Control (management) malaria mosquito Review Biology Microbiology 03 medical and health sciences parasitic diseases medicine Humans genome editing Gene Drive Technology Public Health Environmental and Occupational Health Gene drive General Medicine medicine.disease Technical progress Mosquito control 030104 developmental biology Infectious Diseases Risk analysis (engineering) CRISPR Parasitology genetic vector control Malaria |
| Zdroj: | Pathogens and Global Health |
| ISSN: | 2047-7732 2047-7724 |
| DOI: | 10.1080/20477724.2017.1453587 |
| Popis: | Self-propagating gene drive technologies have a number of desirable characteristics that warrant their development for the control of insect pest and vector populations, such as the malaria-transmitting mosquitoes. Theoretically easy to deploy and self-sustaining, these tools may be used to generate cost-effective interventions that benefit society without obvious bias related to wealth, age or education. Their species-specific design offers the potential to reduce environmental risks and aim to be compatible and complementary with other control strategies, potentially expediting the elimination and eradication of malaria. A number of strategies have been proposed for gene-drive based control of the malaria mosquito and recent demonstrations have shown proof-of-principle in the laboratory. Though several technical, ethical and regulatory challenges remain, none appear insurmountable if research continues in a step-wise and open manner. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|