Triglyceride-to-high density lipoprotein cholesterol ratio predicts clinical outcomes in patients with gastric cancer
| Autor: | Zhenlin Nie, Yishan Wang, Zemu Wang, Guo-Xing Zhang, Yanping Mei, Xiaoqin Huang, Huiling Sun, Shukui Wang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty clinical outcome Blood lipids Single Center Gastroenterology nomogram 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine High-density lipoprotein high density lipoprotein cholesterol Internal medicine Case fatality rate medicine triglyceride Triglyceride Cholesterol business.industry gastric cancer Cancer Nomogram medicine.disease 030104 developmental biology Oncology chemistry 030220 oncology & carcinogenesis lipids (amino acids peptides and proteins) business Research Paper |
| Zdroj: | Journal of Cancer |
| ISSN: | 1837-9664 |
| Popis: | Correlation of triglyceride (TG)-to-high density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C) and the survival of gastric cancer (GC) remain unclear. The purpose of this study was to explore the precise effect of preoperative TG/HDL-C on clinical outcomes in GC patients. Patients with GC were enrolled from 2006 to 2014. A total of 957 individuals from a single center were divided into prospective training and retrospective test cohorts. The optimal cutoff value of TG/HDL-C was determined using X-tile software to separate the training cohort into low and high survival groups according to TG/HDL-C levels. Survival analyses were performed using Kaplan-Meier curves and a Cox proportional hazards regression model. Preoperative TG/HDL-C and clinical outcomes were obtained to determine the prognostic significance of serum lipids in the training and test cohorts. We observed that high TG and TG/HDL-C were significantly correlated with poor outcome in GC patients, and high TG/HDL-C harbored the highest area under curve to independently predict 5-year overall survival in two cohorts. Furthermore, c-index of the prognostic nomogram including TG/HDL-C was significantly higher than that without it. In summary, TG/HDL-C was an efficient and independent prognostic factor to predict 5-year case fatality of GC patients and to improve the efficacy of its prognostic nomogram. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|