A Neglected Case of Multifocal Liposarcoma Presented in Five Different Sites in a Syrian Woman: A case report
| Autor: | Ahmad Ghazal, Amna Ibrahim, Ahmad Al-Haj, Ruqaya Masri, Ieman Alawad |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Poor prognosis Round cell Round Cell Liposarcoma Case presentation Liposarcoma Article World health 03 medical and health sciences 0302 clinical medicine Multifocal disease Case report Rare case medicine Multifocal neoplasms business.industry Soft tissue sarcoma medicine.disease body regions 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Surgery Radiology business |
| Zdroj: | International Journal of Surgery Case Reports |
| ISSN: | 2210-2612 |
| DOI: | 10.1016/j.ijscr.2019.10.077 |
| Popis: | Highlights • Complete surgical resection of liposarcoma is central in treatment based on grade. • Radiation reduces risk of local recurrence or minimize surgical morbidity in the highly radiosensitive myxoid/round cell liposarcoma group. • Chemotherapy is utilized in chemosensitive histologies with metastatic potential. • Understanding of the genetic aberrations allows development of targeted therapies for liposarcoma. Introduction Multifocal soft tissue sarcoma is a rare clinical entity occurring in 1 % of patients with extremity soft tissue sarcoma and in 4.5 % of patients with liposarcoma. Multifocal disease may arise either synchronously or metachronously and has been associated with poor prognosis. Case presentation Herein, we report a rare case of a Syrian woman patient with six different foci of liposarcoma in five sites at the time of diagnosis. Discussion Liposarcomas are currently classified into four different subtypes based on histologic or genetic analysis according to the World Health Organization (WHO), including cell-differentiated, dedifferentiated, myxoid, and pleomorphic. In the present work, we report a neglected patient with a multicentric round cell liposarcoma in five different sites. Conclusion Medicine cannot provide much care for these advanced cases of multicentric liposarcoma so far. Therefore, more research should be conducted to improve the ability to manage these entities and to identify potential novel therapies. |
| Databáze: | OpenAIRE |
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