Distribution of bovine alpha-herpesviruses and expression of toll-like receptors in the respiratory system of experimentally infected calves
| Autor: | Silvina Quintana, Anselmo Carlos Odeón, Sandra Perez, Maia Solange Marin, Maria Rosa Leunda |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
BOVINE HERPESVIRUSES
0301 basic medicine Otras Biotecnología Agropecuaria Biotecnología Agropecuaria Respiratory System Cattle Diseases Alpha (ethology) Biology 03 medical and health sciences TOLL-LIKE RECEPTOR Downregulation and upregulation medicine Animals EXPRESSION PATTERNS Respiratory system Receptor Infectious Bovine Rhinotracheitis Herpesvirus 1 Bovine Regulation of gene expression Herpesvirus 5 Bovine Toll-like receptor General Veterinary RESPIRATORY SYSTEM Toll-Like Receptors Virology Up-Regulation 030104 developmental biology medicine.anatomical_structure Gene Expression Regulation CIENCIAS AGRÍCOLAS Immunology TLR3 Cattle Respiratory tract |
| Zdroj: | Research in Veterinary Science. 105:53-55 |
| ISSN: | 0034-5288 |
| Popis: | This study provides an initial analysis of the toll-like receptors (TLRs) that might be implicated in alpha-herpesvirus infection of the bovine respiratory system. A significant variation in the expression of TLR3 and TLRs 7–9 during bovine herpesvirus type 1 (BoHV-1) and 5 (BoHV-5) acute infections and particularly an up-regulation during viral reactivation in respiratory tissues has been demonstrated. Furthermore, viral distribution in the respiratory tract of BoHV-1- and BoHV-5-infected calves at different stages of the infectious cycle was analysed. The wide distribution of BoHV DNA in the respiratory tract during acute infection was restricted during latent infection and the subsequent reactivation of BoHV-1 and BoHV-5. Overall, the findings presented here contribute to the knowledge on the replication and dissemination of bovine alpha-herpesviruses. Furthermore, some of the immune factors triggered in the host that determine the different outcomes of infection by two closely related pathogens of cattle have been elucidated. Fil: Marin, Maia Solange. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Quintana, Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Análisis Fares Taie; Argentina Fil: Leunda, Maria Rosa. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce; Argentina Fil: Odeón, Anselmo Carlos. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Sur. Estación Experimental Agropecuaria Balcarce; Argentina Fil: Perez, Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina |
| Databáze: | OpenAIRE |
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