Aortic Aneurysm as a Complication of Granulomatosis with Polyangiitis Successfully Treated with Prednisolone and Cyclophosphamide: A Case Report and Review of the Literature
| Autor: | Keigo Ikeda, Takuya Hirai, Iwao Sekigawa, Naoko Niimi, Shinji Morimoto, Kozo Watanabe, Tomoko Miyashita, Kana Tanji |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
lcsh:Diseases of the musculoskeletal system Cyclophosphamide Case Report Lung biopsy macromolecular substances 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences Aortic aneurysm 0302 clinical medicine Proteinase 3 Internal medicine medicine cardiovascular diseases 030203 arthritis & rheumatology Lung business.industry General Medicine medicine.disease Abdominal aortic aneurysm medicine.anatomical_structure Prednisolone cardiovascular system lcsh:RC925-935 Granulomatosis with polyangiitis business medicine.drug |
| Zdroj: | Case Reports in Rheumatology Case Reports in Rheumatology, Vol 2018 (2018) |
| ISSN: | 2090-6897 2090-6889 |
| Popis: | A 57-year-old Japanese man was admitted to the hospital with back pain and fever, multiple lung nodules, and abdominal aortic aneurysm (AAA). Laboratory tests performed at admission showed an increased proteinase 3 anti-neutrophil cytoplasmic antibody (PR3-ANCA) level. Video-associated thoracoscopic lung biopsy was performed; pathologic examination showed granulation tissue with necrosis and multinucleated giant cells. The diagnosis of granulomatosis with polyangiitis (GPA) was confirmed on the basis of the clinical presentation, laboratory findings, and lung biopsy. All symptoms were ameliorated, and the serum level of PR3-ANCA declined following treatment with prednisolone and cyclophosphamide. Although the association of GPA with AAA is rare, GPA may be included among the large vessel vasculitides that can give rise to aortic aneurysm. |
| Databáze: | OpenAIRE |
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