Clinical characteristics and etiology of bacterial meningitis in Chinese children >28 days of age, January 2014–December 2016: A multicenter retrospective study
| Autor: | Yu-jiao Wang, Yan-jun Han, Na Li, Gang Liu, Guo Zheng, Fang-chao Zhao, Xiao-tao Yang, Juan Chen, Ai-wei Lin, Jing Bi, Jun Liang, Chi Li, Qiong Luo, Dong-meng Wang, Yonghong Yang, Liang Ru, Qiao-zhi Yang, Yongjun Li, Ping Jin, Xiong-ying Yu, Jianmin Zhong, Yan-chun Wang, Jie Yu, Jikui Deng, Lingyun Guo, Wen-ya Feng |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Microbiology (medical) China medicine.medical_specialty Cefotaxime Adolescent 030106 microbiology Microbial Sensitivity Tests medicine.disease_cause Group B Meningitis Bacterial Streptococcus agalactiae lcsh:Infectious and parasitic diseases 03 medical and health sciences 0302 clinical medicine Antibiotic resistance Internal medicine Drug Resistance Bacterial Streptococcus pneumoniae Escherichia coli medicine Humans lcsh:RC109-216 030212 general & internal medicine Child Retrospective Studies business.industry Streptococcus Ceftriaxone Infant Penicillin G General Medicine Anti-Bacterial Agents Penicillin Infectious Diseases Child Preschool Etiology Female business medicine.drug |
| Zdroj: | International Journal of Infectious Diseases, Vol 74, Iss, Pp 47-53 (2018) |
| ISSN: | 1201-9712 |
| Popis: | Objective: To explore the clinical characteristics and etiology of bacterial meningitis (BM) in Chinese children. Method: BM cases in children 28 days to 18 years old were collected from January 2014–December 2016 and screened according to World Health Organization standards. Clinical features, pathogens, and resistance patterns were analyzed. Results: Overall, 837 cases were classified into five age groups: 28 days–2 months (17.0%), 3–11 months (27.8%), 12–35 months (24.0%), 3–6 years (13.9%), and >6 years (17.3%). Major pathogens were Streptococcus pneumoniae (S. pneumoniae, n = 136, 46.9%), group B Streptococcus (GBS, n = 29, 10.0%), and Escherichia coli (E. coli, n = 23, 7.9%). In infants 3 months old, S. pneumoniae (54.7%), which had a penicillin non-susceptibility rate of 55.4% (36/65), was most frequent. The resistance rates of S. pneumoniae and E. coli to cefotaxime and ceftriaxone were 14.0%/40.0% and 11.3%/68.4%, respectively. All GBS isolates were sensitive to penicillin. Conclusions: The occurrence of BM peaked in the first year of life, while S. pneumoniae was the predominant pathogen in children >3 months of old. The antibiotic resistance of S. pneumoniae was a concern. Keywords: Bacterial meningitis, Children, Pathogen, Antibiotic susceptibility |
| Databáze: | OpenAIRE |
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