Is there any relationship between gene expression of tumor antigens and CD4+ T cells in multiple myeloma?
| Autor: | Veruska Lia Fook Alves, Djordje Atanackovic, Bruna Raphaeli Silva, Gisele W. B. Colleoni, Walter Moises Tobias Braga, Adriana Bruscato Bortoluzo |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Pathology medicine.medical_specialty medicine.medical_treatment Plasma Cells Immunology Biology Antigen Antigens Neoplasm Bone Marrow Gene expression Biomarkers Tumor medicine Humans Immunology and Allergy Multiple myeloma Aged Aged 80 and over FOXP3 Immunotherapy Middle Aged medicine.disease Neoplasm Proteins Gene Expression Regulation Neoplastic Real-time polymerase chain reaction medicine.anatomical_structure Oncology Cancer research Cancer/testis antigens Female Bone marrow Multiple Myeloma |
| Zdroj: | Immunotherapy. 6:569-575 |
| ISSN: | 1750-7448 1750-743X |
| DOI: | 10.2217/imt.14.24 |
| Popis: | Aim: The present study aimed at correlating the expression of cancer/testis antigens (CTAs) with the expression of genes related to tumor‐infiltrating T cells. Materials & methods: MAGE‐C1/CT‐7, MAGEA3/6, NY‐ESO‐1, LAGE‐1 and GAGE expression were evaluated in 46 bone marrow multiple myeloma (MM) aspirates by RT‐PCR. Expression of FOXP3/CTLA4 and RORyt, as markers for Tregs and Th17 cells, respectively, was investigated by quantitative PCR. Results: MAGEC1/CT7 was expressed in 66% of MM samples. We did not find correlation between the presence of single CTA and expression of CTLA4 or RORyt neither expression of CD4+ T‐cell markers and the number of CTA simultaneously expressed in the tumor. However, we did observe a correlation between the percentage of plasma cells and the number of CTAs expressed in the patients' bone marrow. Conclusion: Although CTAs and immunomodulatory CD4+ T cells represent potential targets for immunotherapy in MM, we did not find association among expression of such genes in MM. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|