Growth and development of bone mass in untreated alloxan diabetic rats. Effects of collagen glycosylation and parathyroid activity on bone turnover
| Autor: | Hilda Abranzon, Rosa Alloatti, Maria del C. Fernandez, Martha E. Locatto, Puche Rc, D. Caferra |
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| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Glycosylation Parathyroid hormone Bone tissue Biochemistry Bone and Bones Bone resorption Diabetes Mellitus Experimental Bone remodeling Parathyroid Glands chemistry.chemical_compound Endocrinology Bone Density Alloxan Diabetes mellitus Internal medicine medicine Animals Bone Resorption Osteomalacia Bone Development Body Weight medicine.disease Rats medicine.anatomical_structure chemistry Collagenase Surgery Collagen medicine.drug |
| Zdroj: | Bone and Mineral. 23:129-144 |
| ISSN: | 0169-6009 |
| Popis: | Body and skeletal growth and development were studied in alloxan-treated and age-matched control rats, between 3 and 23 weeks of age. For both groups the growth of the skeletal and body weights were in phase, with a maximum at 7 weeks of age. The growth data was assessed according to Parks' theory of feeding and growth. Alloxan-treated rats showed an important reduction in body and bone mass, with a greater impact on soft tissues. As expected, the asymptotic body and skeletal weights were reduced respect to controls. The time needed to attain 63% of mature food intake (Brody's ‘time constant’) was also reduced, indicating that maturation occurred at an earlier age than controls. The diabetic state is characterized by a reduced food conversion efficiency. Despite hyperfagia, alloxan-treated rats showed circa one-half the body and skeletal weights of age-matched controls. The following adverse effects of alloxan diabetes on bone tissue were observed: (a) a decrease in trabecular bone volume (femoral metaphyses) and cortical width (femoral diaphyses), (b) increased bone collagen glycosylation as a function of extracellular glucose concentration, (c) increased resistance of bone collagen to collagenase hydrolysis, (d) decreased rate of bone resorption except under strongly stimulated parathyroid function, (d) significantly lower ashes/bone matrix ratio in diabetic rats with more than 10 weeks of diabetes, and (e) no histological evidence of osteomalacia. |
| Databáze: | OpenAIRE |
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