High mRNA expression of LY6 gene family is associated with overall survival outcome in pancreatic ductal adenocarcinoma
| Autor: | Benjamin Jin, Geeta Upadhyay, Michele M. Gage, Subha Madhavan, Yuriy Gusev, Eric Russ, Krithika Bhuvaneshwar, Guisong Wang |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
survival outcome Tumor microenvironment business.industry pancreatic cancer Context (language use) medicine.disease LY6 genes 03 medical and health sciences immune cells 030104 developmental biology 0302 clinical medicine Immune system Text mining Oncology 030220 oncology & carcinogenesis Pancreatic cancer Cancer research Medicine Gene family Stem cell business Gene Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | Pancreatic cancer ranks one of the worst in overall survival outcome with a 5 year survival rate being less than 10%. Pancreatic cancer faces unique challenges in its diagnosis and treatment, such as the lack of clinically validated biomarkers and the immensely immunosuppressive tumor microenvironment. Recently, the LY6 gene family has received increasing attention for its multi-faceted roles in cancer development, stem cell maintenance, immunomodulation, and association with more aggressive and hard-to-treat cancers. A detailed study of mRNA expression of LY6 gene family and its association with overall survival (OS) outcome in pancreatic cancers is lacking. We used publicly available clinical datasets to analyze the mRNA expression of a set of LY6 genes and its effect on OS outcome in the context of the tumor microenvironment and immunomodulation. We used web-based tools Kaplan-Meier Plotter, cBioPortal, Oncomine and R-programming to analyze copy number alterations, mRNA expression and its association with OS outcome in pancreatic cancer. These analyses demonstrated that high expression of LY6 genes is associated with OS and disease free survival (DFS) outcome. High expression of LY6 genes and their association with OS outcome is dependent on the composition of tumor microenvironment. Considering that LY6 proteins are anchored to the outer cell membrane or secreted, making them readily accessible, these findings highlight the potential of LY6 family members in the future of pancreatic cancer diagnosis and treatment. |
| Databáze: | OpenAIRE |
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