Adherence and long-term outcomes of growth hormone therapy with easypod™ in pediatric subjects: Spanish ECOS study
| Autor: | María Dolores Rodríguez Arnao, Amparo Rodríguez Sánchez, Ignacio Díez López, Joaquín Ramírez Fernández, Jose Antonio Bermúdez de la Vega, Diego Yeste Fernández, María Chueca Guindulain, Raquel Corripio Collado, Jacobo Pérez Sánchez, Ana Fernández González |
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| Přispěvatelé: | [Rodríguez Arnao MD, Rodríguez Sánchez A] Pediatric Endocrinology Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain. [Díez López I] Hospital Universitario Araba, Alava, Spain. [Ramírez Fernández J] Hospital Universitario Príncipe de Asturias, Oviedo, Spain. [Bermúdez de la Vega JA] Centro Nuevas Tecnologias, Sevilla, Spain. [Yeste Fernández D] Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| Rok vydání: | 2019 |
| Předmět: |
Pediatrics
medicine.medical_specialty pediatrics Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Growth hormone Somatotropina outcomes lcsh:Diseases of the endocrine glands. Clinical endocrinology equipos y suministros::equipos eléctricos y suministros eléctricos::dispositivos electrónicos ponibles [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS] r-hGH electronic device 03 medical and health sciences 0302 clinical medicine Endocrinology Electrònica mèdica Turner syndrome Internal Medicine medicine Long term outcomes 030212 general & internal medicine adherence Equipment and Supplies::Electrical Equipment and Supplies::Wearable Electronic Devices [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT] Hormones Hormone Substitutes and Hormone Antagonists::Hormones::Peptide Hormones::Pituitary Hormones::Pituitary Hormones Anterior::Growth Hormone::Human Growth Hormone [CHEMICALS AND DRUGS] easypod long-term lcsh:RC648-665 business.industry hormonas sustitutos de hormonas y antagonistas de hormonas::hormonas::hormonas peptídicas::hormonas hipofisarias::hormonas adenohipofisarias::hormona del crecimiento::hormona del crecimiento humana [COMPUESTOS QUÍMICOS Y DROGAS] Research medicine.disease Study Characteristics::Multicenter Study [PUBLICATION CHARACTERISTICS] Small for gestational age e-health Observational study business características del estudio::estudio multicéntrico [CARACTERÍSTICAS DE PUBLICACIONES] GH Deficiency |
| Zdroj: | Endocrine Connections Scientia Endocrine Connections, Vol 8, Iss 9, Pp 1240-1249 (2019) |
| ISSN: | 2049-3614 |
| Popis: | Background Non-adherence to r-hGH treatments occurs in a variable percentage of subjects. One problem found when evaluating adherence is the great variability in methods of detection and definitions utilized in studies. This study assessed the level of adherence in subjects receiving r-hGH with the easypod™ electronic device. Methods National, multicenter, prospective and observational study involving 238 subjects (144 with GH deficiency (GHD), and 86 with small for gestational age (SGA), 8 with Turner Syndrome), who received r-hGH with easypod™ for at least 3 months before inclusion. The follow-up period was 4 years. Results Overall adherence was 94.5%; 97.5% after 6 months, 95.3% after 1 year, 93.7% after 2, 94.4% after 3 and 95.5% after 4 years of treatment. No differences in adherence were observed between prepubertal and pubertal groups and GHD and SGA groups. Change in height after 1 and 2 years, change in height SDS after 1 and 2 years, HV after 1 year, HV SDS after at 1 and 4 years, change in BMI after 1 year and change in BMI SDS at 1 and 2 years showed significant correlation with adherence. No significant differences in adherence according to IGF-I levels were found in follow-up visits or between groups. Conclusions The easypod™ electronic device, apart from being a precise and objective measure of adherence to r-hGH treatment, allows high compliance rates to be achieved over long periods of time. Adherence significantly impacts growth outcomes associated with r-hGH treatment. |
| Databáze: | OpenAIRE |
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