Hybridization Approach Toward Novel Antituberculars: Design, Synthesis, and Biological Evaluation of Compounds Combining Pyrazinamide and 4-Aminosalicylic Acid
| Autor: | Ghada Bouz, Petr Šlechta, Ondřej Jand’ourek, Klára Konečná, Pavla Paterová, Pavel Bárta, Martin Novák, Radim Kučera, Nils-Jørgen Knudsen Dal, Federico Fenaroli, Júlia Zemanová, Martin Forbak, Jana Korduláková, Oto Pavliš, Pavla Kubíčková, Martin Doležal, Jan Zitko |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | ACS infectious diseases. |
| ISSN: | 2373-8227 |
| Popis: | Apart from the SARS-CoV-2 virus, tuberculosis remains the leading cause of death from a single infectious agent according to the World Health Organization. As part of our long-term research, we prepared a series of hybrid compounds combining pyrazinamide, a first-line antitubercular agent, and 4-aminosalicylic acid (PAS), a second-line agent. Compound |
| Databáze: | OpenAIRE |
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