T cell ALL in a child with Ataxia telangiectasia; diagnosis and management challenges
| Autor: | Omaima Ahmed, Yara Felimban, Abeer Almehdar |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty medicine.medical_treatment T cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 03 medical and health sciences Ataxia Telangiectasia 0302 clinical medicine Antineoplastic Combined Chemotherapy Protocols Medicine Humans Family history Genetic testing Chemotherapy medicine.diagnostic_test business.industry Childhood Lymphoma Brain Disease Management Infant Hematology medicine.disease Regimen medicine.anatomical_structure 030220 oncology & carcinogenesis Toxicity Ataxia-telangiectasia business 030215 immunology |
| Zdroj: | Hematology (Amsterdam, Netherlands). 26(1) |
| ISSN: | 1607-8454 |
| Popis: | Ataxia telangiectasia (A-T) is a rare childhood autosomal recessive neurodegenerative chromosomalin stability disorder. It is characterized by high risk of hematological malignancies with T-cell phenotype being the most common, which can present first before the diagnosis of A-T made. The chromosomalin stability in A-T increases the toxicity to radio-chemotherapeutic agents, creating the treatment modification challenges and the deviation from the optimal management protocols. In this case report, we present a 14-month-old boy diagnosed as T cell -ALL. Based on his early presentation, family history of childhood lymphoma, and high AFP, inherited predisposition was suspected, and genetic testing confirms A-T. This report represents the crucial part of clinical suspicion of A-T in similar cases as well as highlighting the importance of an early A-T diagnosis that prevents toxic death due to the extensive regimen of radio- chemotherapeutic agents. The report summarizes the toxicity and modification challenges during management with literature review for the chemotherapy modification experience in such cases. |
| Databáze: | OpenAIRE |
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