Association of down-regulation of CD109 expression with up-expression of Smad7 in pathogenesis of psoriasis
| Autor: | Yi-min He, Xinxin Liu, Yan Wu, Shanjuan Chen, Xin Lian, Aiping Feng, Yating Tu, Yan Li, Jiawen Li, Feng Hu |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Adult Male Adolescent Biomedical Engineering Down-Regulation GPI-Linked Proteins Biochemistry Smad7 Protein Biomaterials Pathogenesis 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Antigens CD Transforming Growth Factor beta Psoriasis Genetics medicine Humans Earth-Surface Processes integumentary system biology business.industry Transforming growth factor beta Middle Aged medicine.disease Neoplasm Proteins Up-Regulation 030104 developmental biology 030220 oncology & carcinogenesis Case-Control Studies Immunology biology.protein Immunohistochemistry Female Signal transduction Normal skin business Transforming growth factor Signal Transduction |
| Zdroj: | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. 36(1) |
| ISSN: | 1993-1352 |
| Popis: | Transforming growth factor (TGF)-β signaling plays an important role in the pathogenesis of psoriasis. CD109, a novel TGF-β co-receptor, which inhibits TGF-β signaling by enhancing Smad7-dependent degradation of TGF-β type I receptor (TGF-β RI), is abnormally expressed in psoriasis. To date, the expression of Smad7 and the correlation between CD109 and Smad7 expression in psoriasis have not been fully elucidated. This study was designed to investigate the expression and the correlation of CD109 and TGF-β signaling associated proteins in psoriasis and their roles in the pathogenesis of psoriasis. Thirty-two psoriasis specimens were subjected to immunohistochemical staining for CD109, Smad7, TGF-β RI and Ki67. Ten normal skin (NS) specimens served as controls. The positive expression rate (% positive cells) of Smad7 and Ki67 in psoriasis was significantly higher than in NS (62.6%±19.9% vs. 17.2%±4.4%, and 50.7%±14.3% vs. 19.5%±3.2%, respectively, P |
| Databáze: | OpenAIRE |
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