C-Reactive Protein in Stable Cystic Fibrosis: An Additional Indicator of Clinical Disease Activity and Risk of Future Pulmonary Exacerbations
| Autor: | Elias Matouk, Dao Nguyen, Larry C. Lands, Andrea Benedetti, Simon Rousseau, Danuta Radzioch, Jennifer S. Landry, Joanie Bernier, James Gruber, Heather G. Ahlgren, Gabriella Wojewodka |
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| Rok vydání: | 2016 |
| Předmět: |
Quality of life
medicine.medical_specialty Pathology Clinical variables Clinical scoring Clinical disease severity Systemic biomarkers Cystic fibrosis Gastroenterology Article 03 medical and health sciences 0302 clinical medicine Disease severity Internal medicine Medicine 030212 general & internal medicine Inflammation biology business.industry C-reactive protein Clinical disease medicine.disease Lung function 3. Good health Increased risk 030228 respiratory system Cohort biology.protein business Chronic pulmonary infections |
| Zdroj: | Journal of pulmonary & respiratory medicine |
| ISSN: | 2161-105X |
| DOI: | 10.4172/2161-105x.1000375 |
| Popis: | Introduction: In stable adult cystic fibrosis (CF) patients, we assessed the role of baseline high sensitivity C-reactive protein (hs-CRP) on CF clinical variables and frequency of intravenous (IV) treated pulmonary exacerbations (PExs) 1-year post- baseline. Methods: We recruited 51 clinically stable CF patients from our Adult CF Center. We incorporated collected parameters into Matouk CF clinical score and CF questionnaire-revised quality of life score (QOL). We used the clinical minus complications subscores as a clinical disease activity score (CDAS). We dichotomized our patients according to the cohort median baseline hs-CRP of 5.2 mg/L. Results: Patients in the high hs-CRP group (≥ 5.2 mg/L) demonstrated worse CDAS (r=0.67, p=0.0001) and QOL scores (r=0.57, p=0.0017) at a given FEV1 % predicted. In both hs-CRP groups, prior-year IV-treated PExs and baseline CDASs were significant predictors of future IV-treated PExs. Interestingly, the association between baseline CDAS and future PExs frequency was more robust in the high compared to the low hs-CRP group (r=–0.88, p |
| Databáze: | OpenAIRE |
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