Effectiveness of seasonal influenza vaccinations against laboratory-confirmed influenza-associated infections among Singapore military personnel in 2010-2013

Autor:	Junxiong Pang, Christine Gao, Li Wei Ang, Vernon J. Lee, Alex R. Cook, Hin Peow Ho, Xiahong Zhao, Li Yang Hsu, Raymond Tzer-Pin Lin, Mark I-Cheng Chen
Rok vydání:	2014
Předmět:	Pulmonary and Respiratory Medicine Adult Male medicine.medical_specialty Veterinary medicine Adolescent Epidemiology Influenza vaccine influenza A(H1N1)pdm09 medicine.disease_cause Seasonal influenza Young Adult Internal medicine Influenza Human medicine Influenza A virus Humans influenza A(H3N2) influenza B Singapore vaccine effectiveness business.industry Public Health Environmental and Occupational Health virus diseases Influenza a Original Articles Middle Aged influenza vaccination Vaccination Military personnel Influenza B virus Infectious Diseases Military Personnel Influenza Vaccines Female Seasons business
Zdroj:	Influenza and Other Respiratory Viruses
ISSN:	1750-2659
Popis:	Background Limited information is available about seasonal influenza vaccine effectiveness (VE) in tropical communities. Objectives Virus subtype-specific VE was determined for all military service personnel in the recruit camp and three other non-recruit camp in Singapore's Armed Forces from 1 June 2009 to 30 June 2012. Methods Consenting servicemen underwent nasal washes, which were tested with RT-PCR and subtyped. The test positive case and test negative control design was used to estimate the VE. To estimate the overall effect of the programme on new recruits, we used an ecological time series approach. Results A total of 7016 consultations were collected. The crude estimates for the VE of the triavalent vaccine against both influenza A(H1N1)pdm09 and influenza B were 84% (95% CI 78–88%, 79–86%, respectively). Vaccine efficacy against influenza A(H3N2) was markedly lower (VE 33%, 95% CI −4% to 57%). An estimated 70% (RR = 0·30; 95% CI 0·11–0·84), 39% (RR = 0·61;0·25–1·43) and 75% (RR = 0·25; 95% CI 0·11–0·50) reduction in the risk of influenza A(H1N1)pdm09, influenza A(H3N2) and influenza B infections, respectively, in the recruit camp during the post-vaccination period compared with during the pre-vaccination period was observed. Conclusions Overall, the blanket influenza vaccine programme in Singapore's Armed Forces has had a moderate to high degree of protection against influenza A(H1N1)pdm09 and influenza B, but not against influenza A(H3N2). Blanket influenza vaccination is recommended for all military personnel.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f29acba87d57ca0f277e8548bb5a0a https://pubmed.ncbi.nlm.nih.gov/24828687 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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