Rebalancing TGFβ1/BMP signals in exhausted T cells unlocks responsiveness to immune checkpoint blockade therapy

Autor: Abbey A. Saadey, Amir Yousif, Nicole Osborne, Roya Shahinfar, Yu-Lin Chen, Brooke Laster, Meera Rajeev, Parker Bauman, Amy Webb, Hazem E. Ghoneim
Rok vydání: 2022
Předmět:
Zdroj: Nature Immunology. 24:280-294
ISSN: 1529-2916
1529-2908
DOI: 10.1038/s41590-022-01384-y
Popis: T cell dysfunctionality prevents the clearance of chronic infections and cancer. Furthermore, epigenetic programming in dysfunctional CD8
Databáze: OpenAIRE
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