Brain-derived Neurotrophic Factor (BDNF) and gray matter volume in bipolar disorder
| Autor: | F. Benedetti, Annemarie J. M. Wijkhuijs, Hemmo A. Drexhage, Cristina Colombo, H J de Wit, Oliver Ambrée, Thomas A. Hoogenboezem, Clara Locatelli, Sara Poletti, Volker Arolt, Veronica Aggio |
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| Přispěvatelé: | Poletti, S., Aggio, V., Hoogenboezem, T. A., Ambrã©e, O., de Wit, H., Wijkhuijs, A. J. M., Locatelli, C., Colombo, C., Arolt, V., Drexhage, H. A., Benedetti, F, Immunology |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Bipolar disorder Lithium Grey matter Gyrus Cinguli 03 medical and health sciences Superior temporal gyrus 0302 clinical medicine Neuroinflammation Neurotrophic factors Internal medicine medicine Humans Middle frontal gyrus Gray Matter Gray matter Anterior cingulate cortex Cerebral Cortex Brain-derived neurotrophic factor Depressive Disorder Major Fusiform gyrus Brain-Derived Neurotrophic Factor Brain Middle Aged 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure Endocrinology BDNF Psychiatry and Mental Health Case-Control Studies Female Psychology Neuroscience Biomarkers 030217 neurology & neurosurgery Parahippocampal gyrus |
| Zdroj: | European Psychiatry, 40, 33-37. Cambridge University Press |
| ISSN: | 0924-9338 |
| DOI: | 10.1016/j.eurpsy.2016.06.008 |
| Popis: | IntroductionBipolar Disorder (BD) is a severe psychiatric condition characterized by grey matter (GM) volumes reduction. Neurotrophic factors have been suggested to play a role in the neuroprogressive changes during the illness course. In particular peripheral brain-derived neurotrophic factor (BDNF) has been proposed as a potential biomarker related to disease activity and neuroprogression in BD. The aim of our study was to investigate if serum levels of BDNF are associated with GM volumes in BD patients and healthy controls (HC).MethodsWe studied 36 inpatients affected by a major depressive episode in course of BD type I and 17 HC. Analysis of variance was performed to investigate the effect of diagnosis on GM volumes in the whole brain. Threshold for significance was P < 0.05, Family Wise Error (FWE) corrected for multiple comparisons. All the analyses were controlled for the effect of nuisance covariates known to influence GM volumes, such as age, gender and lithium treatment.ResultsBD patients showed significantly higher serum BDNF levels compared with HC. Reduced GM volumes in BD patients compared to HC were observed in several brain areas, encompassing the caudate head, superior temporal gyrus, insula, fusiform gyrus, parahippocampal gyrus, and anterior cingulate cortex. The interaction analysis between BDNF levels and diagnosis showed a significant effect in the middle frontal gyrus. HC reported higher BDNF levels associated with higher GM volumes, whereas no association between BDNF and GM volumes was observed in BD.DiscussionOur study seems to suggest that although the production of BDNF is increased in BD possibly to prevent and repair neural damage, its effects could be hampered by underlying neuroinflammatory processes interfering with the neurodevelopmental role of BDNF. |
| Databáze: | OpenAIRE |
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