Host Range and Coding Potential of Eukaryotic Giant Viruses
Autor: | Tzu-Haw Wang, Tsu-Wang Sun, Ming-Wei Lai, Tzu-Tong Kao, Chia-Ling Yang, Chuan Ku |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Genome evolution host switch 030106 microbiology lcsh:QR1-502 Nucleo-Cytoplasmic Large DNA Viruses (NCLDVs) Review Genome Viral genome evolution cophylogeny Genome Host Specificity lcsh:Microbiology Evolution Molecular 03 medical and health sciences Genome Size Virology lateral gene transfers Animals Humans Giant Virus Mimiviridae Gene Genome size Phylogeny algae protists Comparative genomics biology gene repertoire Eukaryota Genomics biology.organism_classification 030104 developmental biology Infectious Diseases auxiliary genes Evolutionary biology Giant Viruses Phycodnaviridae virus-encoded metabolism |
Zdroj: | Viruses, Vol 12, Iss 1337, p 1337 (2020) Viruses |
ISSN: | 1999-4915 |
Popis: | Giant viruses are a group of eukaryotic double-stranded DNA viruses with large virion and genome size that challenged the traditional view of virus. Newly isolated strains and sequenced genomes in the last two decades have substantially advanced our knowledge of their host diversity, gene functions, and evolutionary history. Giant viruses are now known to infect hosts from all major supergroups in the eukaryotic tree of life, which predominantly comprises microbial organisms. The seven well-recognized viral clades (taxonomic families) have drastically different host range. Mimiviridae and Phycodnaviridae, both with notable intrafamilial genome variation and high abundance in environmental samples, have members that infect the most diverse eukaryotic lineages. Laboratory experiments and comparative genomics have shed light on the unprecedented functional potential of giant viruses, encoding proteins for genetic information flow, energy metabolism, synthesis of biomolecules, membrane transport, and sensing that allow for sophisticated control of intracellular conditions and cell-environment interactions. Evolutionary genomics can illuminate how current and past hosts shape viral gene repertoires, although it becomes more obscure with divergent sequences and deep phylogenies. Continued works to characterize giant viruses from marine and other environments will further contribute to our understanding of their host range, coding potential, and virus-host coevolution. |
Databáze: | OpenAIRE |
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