Nuclear organization of the substantia nigra, ventral tegmental area and retrorubral field of the common marmoset (Callithrix jacchus): a cytoarchitectonic and TH-immunohistochemistry study
| Autor: | Judney Cley Cavalcante, Expedito Silva do Nascimento-Júnior, Fausto Pierdoná Guzen, Miriam Stela Maris de Oliveira Costa, Felipe P. Fiuza, José Rodolfo Lopes de Paiva Cavalcanti, Rovena C.G.J. Engelberth, Eudes Euler de Souza Lucena, Jeferson S. Cavalcante, André Luiz Bezerra de Pontes, Kayo Diogenes de A. Silva |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Tyrosine 3-Monooxygenase Tegmentum Mesencephali Substantia nigra Motor Activity Biology Tyrosine-hydroxylase 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Reward Dopamine Retrorubral field biology.animal Callithrix jacchus Neural Pathways Tegmentum medicine Animals Learning Neurons Behavior Tyrosine hydroxylase Raphe Pars compacta Ventral Tegmental Area Marmoset Callithrix Anatomy Immunohistochemistry Substantia nigra pars compacta Substantia Nigra Ventral tegmental area 030104 developmental biology medicine.anatomical_structure nervous system Raphe Nuclei Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Repositório Institucional da UFRN Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
| Popis: | It is widely known that the catecholamine group is formed by dopamine, noradrenaline and adrenaline. Its synthesis is regulated by the enzyme called tyrosine hydroxylase. 3-hydroxytyramine/dopamine (DA) is a precursor of noradrenaline and adrenaline synthesis and acts as a neurotransmitter in the central nervous system. The three main nuclei, being the retrorubral field (A8 group), the substantia nigra pars compacta (A9 group) and the ventral tegmental area (A10 group), are arranged in the die-mesencephalic portion and are involved in three complex circuitries - the mesostriatal, mesolimbic and mesocortical pathways. These pathways are involved in behavioral manifestations, motricity, learning, reward and also in pathological conditions such as Parkinson's disease and schizophrenia. The aim of this study was to perform a morphological analysis of the A8, A9 and A10 groups in the common marmoset (Callithrix jacchus - a neotropical primate), whose morphological and functional characteristics support its suitability for use in biomedical research. Coronal sections of the marmoset brain were submitted to Nissl staining and TH-immunohistochemistry. The morphology of the neurons made it possible to subdivide the A10 group into seven distinct regions: interfascicular nucleus, raphe rostral linear nucleus and raphe caudal linear nucleus in the middle line; paranigral and parainterfascicular nucleus in the middle zone; the rostral portion of the ventral tegmental area nucleus and parabrachial pigmented nucleus located in the dorsolateral portion of the mesencephalic tegmentum. The A9 group was divided into four regions: substantia nigra compacta dorsal and ventral tiers; substantia nigra compacta lateral and medial clusters. No subdivisions were made for the A8 group. These results reveal that A8, A9 and A10 are phylogenetically stable across species. As such, further studies concerning such divisions are necessary in order to evaluate the occurrence of subdivisions that express DA in other primate species, with the aim of characterizing its functional relevance. |
| Databáze: | OpenAIRE |
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