Regulation of Cell Migration by the C2 Domain of the Tumor Suppressor PTEN

Autor:	Myrto Raftopoulou, Alan Hall, Annette J. Self, Sandrine Etienne-Manneville, Sarah Nicholls
Rok vydání:	2004
Předmět:	Tumor suppressor gene Biology Transfection Catalysis Dephosphorylation chemistry.chemical_compound Cell Movement Catalytic Domain Cell Line Tumor Chlorocebus aethiops Phosphoprotein Phosphatases Animals Humans PTEN Phosphatidylinositol Phosphorylation Sequence Deletion C2 domain Multidisciplinary Tumor Suppressor Proteins PTEN Phosphohydrolase Cell migration Glioma Precipitin Tests Phosphoric Monoester Hydrolases Recombinant Proteins Protein Structure Tertiary Phosphothreonine chemistry Lipid phosphatase activity COS Cells Mutation Cancer research biology.protein
Zdroj:	Science. 303:1179-1181
ISSN:	1095-9203 0036-8075
Popis:	PTEN is a tumor suppressor protein that dephosphorylates phosphatidylinositol 3,4,5 trisphosphate and antagonizes the phosphatidylinositol-3 kinase signaling pathway. We show here that PTEN can also inhibit cell migration through its C2 domain, independent of its lipid phosphatase activity. This activity depends on the protein phosphatase activity of PTEN and on dephosphorylation at a single residue, threonine 383 . The ability of PTEN to control cell migration through its C2 domain is likely to be an important feature of its tumor suppressor activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ecd9a13dd08356611ba6fccff5708e https://doi.org/10.1126/science.1092089 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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