Long-term postnatal steroid effect in very low birth weight infants
| Autor: | Young-Ah Youn, Cheong-Jun Moon, In Kyung Sung |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Time Factors Clinical Biochemistry Logistic regression Biochemistry Bayley Scales of Infant Development 03 medical and health sciences 0302 clinical medicine Endocrinology Exposure group 030225 pediatrics Humans Infant Very Low Birth Weight Medicine Nervous System Physiological Phenomena 030212 general & internal medicine Risk factor Toddler Molecular Biology Hydrocortisone Pharmacology Periventricular leukomalacia business.industry Organic Chemistry Infant Newborn medicine.disease Low birth weight Female Steroids medicine.symptom business medicine.drug |
| Zdroj: | Steroids. 125:33-36 |
| ISSN: | 0039-128X |
| Popis: | We examined whether hydrocortisone exposure ≤ 1 week in very low birth weight infants (VLBWI) was associated with poor neurodevelopmental outcomes at corrected 18 months. Further, the clinical factors associated with worse long term outcome were also evaluated. Of a total of 191 VLBWI, the clinical data for these infants relating were retrospectively collected for analysis. Among the 191 VLBWI, 115 (60.2%) infants were exposed to early postnatal hydrocortisone ≤ 1 week of life in our NICU of Seoul St. Mary’s Hospital, The Catholic University of Korea between December 2012 and December 2014. The morbidities were significantly higher in the group with early hydrocortisone exposure group. At corrected age of 18 months, 109/183 (59.6%) infants in the early hydrocortisone exposure group had significantly lower scores in all three (cognitive, language and motor) composites of Bayley Scales of Infant and Toddler Development III. The multivariable logistic regression analysis showed that only periventricular leukomalacia (PVL) is consistently associated with poor long-term outcomes. Our results suggest that early hydrocortisone exposure ≤ 1 week in VLBWI may not increase the risk for poor long-term outcomes compared to those not exposed. Only PVL is considered as a risk factor for poor long-term neurodevelopmental outcomes. |
| Databáze: | OpenAIRE |
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