Tropomyosins in the healthy and diseased nervous system
| Autor: | Shrujna Patel, Merryn Brettle, Thomas Fath |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Central Nervous System Neurons General Neuroscience Actin remodeling Arp2/3 complex macromolecular substances Tropomyosin Biology Actin cytoskeleton Cell biology 03 medical and health sciences Actin remodeling of neurons 030104 developmental biology 0302 clinical medicine Profilin Central Nervous System Diseases biology.protein Animals Humans Cytoskeleton Growth cone 030217 neurology & neurosurgery Actin |
| Zdroj: | Brain research bulletin. 126(Pt 3) |
| ISSN: | 1873-2747 |
| Popis: | Regulation of the actin cytoskeleton is dependent on a plethora of actin-associated proteins in all eukaryotic cells. The family of tropomyosins plays a key role in controlling the function of several of these actin-associated proteins and their access to actin filaments. In order to understand the regulation of the actin cytoskeleton in highly dynamic subcellular compartments of neurons such as growth cones of developing neurons and the synaptic compartment of mature neurons, it is pivotal to decipher the functional role of tropomyosins in the nervous system. In this review, we will discuss the current understanding and recent findings on the regulation of the actin cytoskeleton by tropomyosins and potential implication that this has for the dysregulation of the actin cytoskeleton in neurological diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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